Quantitative comparison of [18F]3F4AP with MRI and other PET radiotracers in a monkey with a prior traumatic brain injury

Conclusions: [18F]3F4AP showed high sensitivity to what appears to be a chronic TBI in a rhesus macaque, suggestive of increased K+channel expression and plausible demyelination. Further investigation with other PET tracers showed reduced perfusion at the site of injury without inflammation or amyloid deposition and possible demyelination. Some of the MR findings (decreased MTR) were consistent with demyelination but not others (reduced T2-FLAIR). Histopathology will be performed when postmortem samples are available to understand what is driving the [18F]3F4AP uptake. Support: R01NS114066 P41EB022544 T32EB013180 S10OD0180035

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Guehl, N., Ramos-Torres, K., Linnman, C., Moon, S.-H., Dhaynaut, M., Wilks, M., Han, P., Ma, C., Neelamegam, R., Zhou, Y.-P., El Fakhri, G., Reich, D., Normandin, M., Brugarolas, P. Tags: Basic Science - New tracers/analysis Source Type: research