Superiority of68Ga-DOTATATE PET/CT compared to18F-FDG PET/CT and MRI of the spine in the detection of spinal bone metastases in metastatic pheochromocytoma and/or paraganglioma

Conclusions: 68Ga-DOTATATE PET/CT showed a significantly superior detection rate of spinal bone metastases compared to 18F-FDG PET/CT and MRI of the spine. Besides providing a three-dimensional analysis of the whole body, it maybe the imaging modality of choice to evaluate metastatic spine disease especially in the treatment planning and response assessment of the molecular radionuclide therapy (mRT: 223RaCl2, 177Lu/90Y DOTA-analogs, 131I-metaiodobenzylguanidine) in patients with bone only metastatic PPGL.Detection rate (%) of spinal bone metastases by 68Ga-DOTATATE, 18F-FDG PET/CT, and MRI of the spineDetection rates68Ga-DOTATATE18F-FDGMRI of the spinePer lesion401/484 (82.9%, 79.2-86.1%)350/484 (72.3%, 68.1-76.3%)262/484 (54.1%, 49.6-58.6%)Per patient41/41 (100%, 91.4-100%)36/41 (87.8%, 73.8-95.9%)39/41 (95.1%, 83.5-99.4%)

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Jha, A., Patel, M., Saboury, B., Millo, C., Ling, A., Shah, R., Chen, C., Meuter, L., Talvacchio, S., Knue, M., Lin, F., Oa{euro}™Sullivan Coyne, G., Chen, A., Nilubol, N., Herscovitch, P., Taieb, D., Civelek, A., Carrasquillo, J., Pacak, K. Tags: NET and Others II Source Type: research