Imaging activated immune response following therapeutic vaccination in an orthotopic glioma model with 89Zr-DFO-OX40 mAb PET
Conclusions: 89Zr-OX40 mAb PET successfully visualized the activation of systemic immune responses that are triggered upon therapeutic vaccination. The increase in 89Zr-OX40 mAb PET signals correlated with treatment efficacy in the glioma model. Our results highlight the ability of 89Zr-OX40 mAb PET to monitor T cells activation in vaccine strategies targeting GBM.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Nobashi, T., Mayer, A., Xiao, Z., Chan, C., Chaney, A., Gambhir, S. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research
More News: Brain | Brain Cancers | Brain Tumor | Cancer | Cancer & Oncology | Cancer Vaccines | CT Scan | Glioma | Immunotherapy | Neurology | Nuclear Medicine | PET Scan | Study | Vaccines | Veterinary Vaccinations