Imaging activated immune response following therapeutic vaccination in an orthotopic glioma model with 89Zr-DFO-OX40 mAb PET

Conclusions: 89Zr-OX40 mAb PET successfully visualized the activation of systemic immune responses that are triggered upon therapeutic vaccination. The increase in 89Zr-OX40 mAb PET signals correlated with treatment efficacy in the glioma model. Our results highlight the ability of 89Zr-OX40 mAb PET to monitor T cells activation in vaccine strategies targeting GBM.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research