GSE151725 Genome-wide methylation changes in maternal microchimeric cells from Mmc+ and Mmclow offspring mice

Contributors : Jiabin Huang ; Denise Ohnezeit ; Nicole Fischer ; Ina A Stelzer ; Christopher Urbschat ; Petra C ArckSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusDuring mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) is largely unknown. We show that MMc induce a preferential differentiation of hematopoietic stem and progenitor cells towards myelopoiesis in bone marrow of fetal mice, and improves resilience against cytomegalovirus infection in neonates. In humans, low MMc counts in cord blood are associated with an increased number of infections in the first year of life primarily in male newborns. Taken together, MMc boost neonatal immunity in mice and humans to mitigate the risk for early life infections.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research