Preparation And Evaluation Of '3 Cap'pulsatile Drug Delivery System Of Ramipril.

CONCLUSION: The design results revealed that an optimum exposure of 1:2 of isopropanol: formaldehyde vapours for sixty minutes resulted in desired release of second pulse of dose after a predetermined lag time of 5 hours as desired. '3Cap' system was successful in achieving floating and pulsed release of hypertensive drug opening a 'new lease of life' to the existing drug molecule. PMID: 32484113 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

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Obesity is a known risk factor for increased morbidity and mortality in the general population [1-4]. Moreover, both overweight and obese patients are more likely to have chronic health conditions including diabetes mellitus, hypertension, hyperlipidemia, asthma, arthritis, and overall poor health status [3]. These comorbidities are classically associated with increased morbidity and mortality. As weight increases past a normal BMI, there is an associated higher risk of death [4]. Despite this, there has been recent evidence to suggest that obese patients may actually have a survival advantage and improved outcomes after s...
Source: Injury - Category: Orthopaedics Authors: Source Type: research
In conclusion, smoking, low fruit intake, and obesity are key modifiable factors for the prevention of cancer and mental disorders. Individuals with poor/fair self-rated health, high psychological distress, asthma, hypertension, arthritis, or diabetes should be targeted for the prevention and screening of cancer and mental disorders.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In a brand-new study, Ivy League researchers report that they’ve isolated a compound in human stem cells called PAPD5 that can treat “telomere diseases” and reverse cellular aging.1 Of course, like many in mainstream medicine, the first thought is how to turn this natural enzyme into a patented drug that targets stem cells to restore telomeres. It’s yet another example of Big Pharma’s attempt to profit from your God-given genes. But you don’t need a “telomere drug” to reverse cellular aging… In a moment, I’ll show you two natural ways you can easily protect your ...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Health Source Type: news
Among the many remarkable things that have happened since the COVID-19 pandemic began is that a lot of our usual medical care has simply stopped. According to a recent study, routine testing for cervical cancer, cholesterol, and blood sugar is down nearly 70% across the country. Elective surgeries, routine physical examinations, and other screening tests have been canceled or rescheduled so that people can stay at home, avoid being around others who might be sick, and avoid unknowingly spreading the virus. Many clinics, hospitals, and doctors’ offices have been closed for weeks except for emergencies. Even if these f...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Health care Healthy Aging Men's Health Women's Health Source Type: blogs
By SIMON YU, MD, LT COL, USA (Ret) Dr. Tom Frieden, former director of the Centers for Disease Control and Prevention (CDC), opened up a new front in the Coronavirus War by saying we don’t just need to treat the acute disease, we need to treat the underlying conditions that make people more susceptible to serious disease progression. He focused on heart disease, and managing mitigating risk factors such as CVD, diabetes, hypertension and smoking in order to increase people’s odds for recovery. The initial focus has been pneumonia and acute respiratory distress syndrome (ARDS), with risk factors including ast...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 CDC chronic disease holistic care Pandemic SDoH Source Type: blogs
Conditions:   Medication Adherence;   Medication Compliance;   Medication Nonadherence;   Hypertension;   Diabetes;   Arthritis;   Chronic Pain;   Anxiety Depression;   Asthma Intervention:   Device: Spencer Sponsors:   Alberta Health Services, Calgary;   Centre for Aging and Brain Health Innovation;   Catalyst Healthcare Ltd. Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Background/Aims: Frailty is mainly due to an age-related decrease in the physiological reserves needed to maintain biological homeostasis, but it can also occur as a result of chronic diseases. The purpose of this study was to identify illnesses associated with frailty in Korean community-dwelling older adults. Methods: This was a cross-sectional study that included 2,936 older adults aged between 70 and 84 years who had completed both interviews and physical function assessments for the Korean Frailty and Aging Cohort Study. Current illnesses diagnosed by physicians were included in the analysis. Th...
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
CONCLUSIONS: Social stigmas related to depression and anxiety may lead to the underreporting of FMD. Chronic disease management programs in Illinois should consider integrating mental health services. PMID: 32133865 [PubMed - as supplied by publisher]
Source: American Journal of Health Promotion : AJHP - Category: International Medicine & Public Health Authors: Tags: Am J Health Promot Source Type: research
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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