Pityriasis Lichenoides Chronica in a Patient With Ankylosing Spondylitis Treated With Etanercept.

CONCLUSION: Pityriasis lichenoides chronica should be included among the broad clinical spectrum of chronic inflammatory skin diseases which may occur during treatment with TNF-alpha antagonists. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.2191. PMID: 32484616 [PubMed - as supplied by publisher]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research

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Condition:   Follicular Lymphoma Interventions:   Diagnostic Test: cfDNA testing;   Other: sample of saliva or fingernail clipping;   Diagnostic Test: pre-treatment test specimen;   Diagnostic Test: PET/CT, CT, or MRI testing Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Acta Haematol
Source: Acta Haematologica - Category: Hematology Source Type: research
Following the Swissmedic approval of Kymriah ® (tisagenlecleucel; Novartis) 2018 for chimeric antigen receptor (CAR)-T cell therapy for adults with relapsed or refractory (r/r) B-lineage ALL and high-grade B-cell lymphomas after failure of ≥2 therapy lines, followed by the approval of Yescarta® (axicabtagen ciloleucel, Kite/Gilead) by Swis smedic in 2019, a growing number of Swiss centers have established CAR-T therapy. In addition, CAR-T therapy is currently explored for other hematologic malignancies, e.g.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Brief Communication Source Type: research
;t Alpár Tamás Masszi András Masszi Csaba Bödör Recent advances in molecular technologies enable sensitive and quantitative assessment of circulating tumor DNA, offering a noninvasive disease monitoring tool for patients with malignant disorders. Here, we demonstrated on four follicular lymphoma cases that circulating tumor DNA based EZH2 mutation analysis performed by a highly sensitive droplet digital PCR method may be a valuable treatment monitoring approach in EZH2 mutant follicular lymphoma. EZH2 variant allele frequencies changed in parallel with the volume of metabolically ac...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Datta Epidemiologic studies have shown that vast majority of lung cancers (85–90%) are causally linked to tobacco smoking. Although much information has been gained about the effects of smoking on various signaling pathways, little is known about how deregulation of miRNAs leads to activation of oncogenes and inhibition of tumor suppressor genes in non-small cell lung cancer (NSCLC). Our previous study showed that smoking inhibits TGF-β-induced tumor suppressor functions through downregulation of Smad3 in lung cancer cells. In order to understand the upstream mechanism of downregulation of Smad3 by s...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsOur discussion details a comprehensive literature review of extramedullary pulmonary involvement in Waldenstrom ’s macroglobulinemia. Establishing a malignant etiology for pleural effusion in Waldenstrom’s macroglobulinemia can be challenging, as standard techniques may be insensitive. Allele-specific polymerase chain reaction for detecting MYD88 L265P mutations is more sensitive for confirming lymphoplas macytic lymphoma/Waldenstrom’s macroglobulinemia in pleural fluid. Extramedullary pulmonary involvement usually presents post-diagnosis of Waldenstrom’s macroglobulinemia and responds we...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 13 June 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Thejus T. Jayakrishnan, Veli Bakalov, Yazan Samhouri, Rodney E. Wegner, Santhosh Sadashiv
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Authors: Wang Y, Ding W Abstract The increased use of several effective novel targeted therapy agents has revolutionized therapy for patients with chronic lymphocytic leukemia (CLL). Disease progression in patients with CLL continues to occur, however. In particular, 3% to 25% of patients treated with a novel agent develop Richter transformation (RT); that is, histologic transformation of CLL to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RT that develops in the novel agent era is frequently associated with adverse molecular alterations, such as TP53 disruption and complex karyotype...
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
CONCLUSIONS: These studies demonstrate that ECP/pentostatin/TBI is well tolerated and associated with adequate engraftment of neutrophils and platelets in patients with lymphomas and MDS. PMID: 32654201 [PubMed - as supplied by publisher]
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
Conclusions: These findings highlight the substantial burden of caring for an individual with CTCL and the importance of including caregiver burden in the health technology assessment review process. A limitation is the hypothetical vignette approach, which meant the TTO participants did not have experience of caring for individuals with CTCL, but were imagining this state. There is also the possibility that they may also be considering the patient experience when responding to the questions. PMID: 32644862 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
More News: Ankylosing Spondylitis | Cutaneous T cell lymphoma | Dermatology | Enbrel | Lymphoma | Pityriasis | Skin | T-cell Lymphoma