A primer on tissue pH and local anesthetic potency.

We present a graphical solution that clarifies the interrelationships between pH, pKa, and degree of ionization by plotting pKa on the x-axis versus the percentage of unionized local anesthetic on the y-axis. The vertical intercept from the x-axis to the pH curves allows rapid and accurate estimation of the degree of ionization of any local anesthetic of known pKa. PMID: 32484400 [PubMed - as supplied by publisher]
Source: Adv Physiol Educ - Category: Universities & Medical Training Authors: Tags: Adv Physiol Educ Source Type: research