Doxycycline Does Not Cut Growth of Abdominal Aortic Aneurysms
WEDNESDAY, June 3, 2020 -- Doxycycline does not significantly reduce aneurysm growth compared with placebo among patients with small infrarenal abdominal aortic aneurysms, according to a study published in the May 26 issue of the Journal of the...
In their work, Omran et al.1 presented an interesting perspective on pre- and post-operative scoring of patients presenting with ruptured abdominal aortic aneurysm (rAAA), demonstrating that in their study population, multiple existing models could predict mortality. The authors compared the Vascular Surgery Study Group of New England Ruptured Abdominal Aortic Aneurysm (VSGNE rAAA) score, a decision support tool, with the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) scores, two outcome prediction scores, and the SOFA score, an illness severity score.
Surgical site infection (SSI) is a common nosocomial post-operative complication that results in increased hospital stay, patient morbidity and mortality1. In open abdominal aortic aneurysm and open lower extremity vascular surgery, the SSI rate ranges between 4.8% - 12% but has been reported higher at up to 47.5%2-5. For infrainguinal arterial revascularisation, deep SSI rates range from 1 - 5%6-8. When graft contamination occurs, a reoperation for graft excision may be required and this greatly increases the amputation and mortality rate9, 10.
This study examined if a diagnosis of depression was association with more rapid AAA growth.Methods: Patients with small AAA measuring between 30 and 50 mm were recruited from surveillance programs at four Australian centres. Maximum AAA diameter was measured by ultrasound imaging using a standardised and reproducible protocol to monitor AAA growth.
The midterm results of endovascular abdominal aortic aneurysm repair (EVAR) with aortic side branch coil embolization during EVAR was evaluated.
CiNPT in comparison to standard post-operative surgical wound care for groin incisions in patients receiving lower limb revascularization or abdominal aortic aneurysm surgery, did not reduce post-operative wound complications, focused on surgical site infections (SSIs). Furthermore, no significant difference in wound complication related re-admissions and re-interventions was observed in our prospective cohort study. The authors suggest further research before introducing ciNPT as standard of care for all patients as post-operative wound care.
The relationship between volume and surgical outcome has been shown for a variety of surgical procedures. The effect in abdominal aortic aneurysm repair continues to be debated. Reliability adjustment has been used as a method to remove statistical noise from hospital level outcomes but its impact on aortic aneurysm repair is not well understood.
In conclusion, our study presents a comprehensive landscape of plasma metabolites in AAA and AS patients, and provides a research direction for pathogenetic mechanisms in atherosclerotic AAA.PMID:34514753 | DOI:10.1631/jzus.B2000713
CONCLUSION: Nanoparticles-loaded pentagalloyl glucose therapy can be an effective treatment option against advanced stage aneurysms to reverse the disease by ameliorating inflammation and restoring arterial homeostasis.PMID:34516951 | DOI:10.1016/j.ejphar.2021.174487
Int Angiol. 2021 Sep 13. doi: 10.23736/S0392-9590.21.04725-8. Online ahead of print.ABSTRACTBACKGROUND: Red cell distribution width (RDW) reflecting impaired erythropoyesis, has been associated with poor prognosis and mortality in several conditions. The aim of this study was to determine the relationship between RDW and the 5-year survival after the endovascular repair of abdominal aortic aneurysms (EVAR) and its ability to improve the discriminative power of a survival predictive score.METHODS: Retrospective analysis of 284 patients undergoing EVAR at a single centre. The pattern of relationship between RDW and survival ...
CONCLUSION: The incisional hernia after open abdominal aortic aneurysm repair affected a high proportion of the intervened patients. Previous abdominal surgery, chronic kidney disease, and smoking habit were independent factors for the development of an incisional hernia.PMID:34511236 | DOI:10.1016/j.ciresp.2021.08.004