Do Older Adults with Low Muscle Mass or Strength, in the Presence of Obesity, Have an Increased Risk of Joint Replacement Over 13 Years?
This study aims to assess whether older adults with low muscle mass or strength, in the presence of obesity, have an increased risk of knee (TKR) and hip replacement (THR) over 13 years. 1082 community-dwelling older adults (51% women; mean age 62.9 ± 7.5 years) were studied at baseline and multiple time points over 13 years. The incidence of TKR and THR was determined by data linkage to National Joint Replacement Registry. Appendicular lean and fat mass were measure d using DXA. Lower-limb muscle strength (LMS) was assessed by dynamometer. Low muscle mass and strength were defined as the lowest sex-specific tertiles for appendicular lean mass (adjusted for height and total body fat mass) and lower-limb strength, respectively. Obesity was defined as the highest sex-specific tertile for total body fat mass. Competing risk regression models were used to estimate the sub-distribution hazard ratio (SHR) for TKR and THR. Over 13 years of follow-up, 6.8% (n = 74/1082) of the participants had a TKR and 4.7% (n = 50/1066) had THR. Participants with the combination of obesity and low muscle strength (SHR 3.36, 95% CI 1.50, 7.53) but low muscle mass (SHR 1.11, 95% CI 0.52, 2.40) had a significantly increased risk of TKR, compared to individuals with neither obesity nor low muscle mass/strength. However, obesity with low muscle strength did not lead to a significantly greater risk of TKR compare...
Publication date: Available online 13 July 2020Source: Obesity Research &Clinical PracticeAuthor(s): Emily Iuzzolino, Yeonsoo Kim
ConclusionWe achieved promising results with this computer-aided diagnosis method that we tried to develop using convolutional neural networks based on transfer learning. This method can help clinicians for the diagnosis of hip osteoarthritis while interpreting plain pelvic radiographs, also provides assistance for a second objective interpretation. It may also reduce the need for advanced imaging methods in the diagnosis of hip osteoarthritis.
Conclusion: The findings show a high prevalence of disordered eating attitude among high school female students in Al-Madinah city. Younger girls and those of the first scholastic level showed higher disordered eating attitude.
Background: Excessive adipose tissue, in the case of common obesity, has been associated with an endocrine-metabolic alteration that contributes to a manifestation of dyslipidemia. To identify mechanisms which are involved in disorders of lipid metabolism, several nutrients have been studied, especially zinc, which act by regulating transcription factors that are important for synthesis and oxidation of lipids and act as an anti-inflammatory and antioxidant nutrient. Thus, the study makes an assessment of the zinc status and biomarkers of cardiovascular risk in obese women. Methods: A case-control study enrolling obese (bo...
Conclusion: Patients with obesity showed a reduced dietary magnesium intake which seems to induce hypomagnesuria as a compensatory mechanism. The marker of oxidative stress evaluated in this study was not influenced by magnesium.
Publication date: October 2020Source: Journal of Functional Foods, Volume 73Author(s): Xianping Li, Yuanming Huang, Liqiong Song, Yuchun Xiao, Shan Lu, Jianguo Xu, Jianguo Li, Zhihong Ren
Authors: Tatsumi Y PMID: 32655109 [PubMed - as supplied by publisher]
Diabetes mellitus is a group of metabolic disorders, characterized by hyperglycemia, resulting from relative insulin deficiency, often on a background of insulin resistance (type 2 diabetes), or (near) absolute insulin deficiency related to autoimmune pathophysiology (type 1 diabetes). The most common form is type 2 diabetes, and its global prevalence is rising as a result of changes in lifestyle and lengthening of life expectancy.1,2 An estimated 463 million people aged 20 to 79 yr have diabetes,3 which corresponds to 9.3% of the adult population and represents a four-fold increase in diabetes prevalence since 1980.4 Pati...
Condition: Clinical Trial Interventions: Behavioral: Family Check-Up 4 Health; Other: Services as Usual Sponsors: Arizona State University; Northwestern University Enrolling by invitation
Conditions: Obesity, Morbid; Metabolic Syndrome; Bariatric Surgery Candidate; Postoperative Complications Interventions: Procedure: SASI Bipartition; Procedure: Gastric bypass Sponsor: Aleris Hospital Not yet recruiting