Do Older Adults with Low Muscle Mass or Strength, in the Presence of Obesity, Have an Increased Risk of Joint Replacement Over 13 Years?

This study aims to assess whether older adults with low muscle mass or strength, in the presence of obesity, have an increased risk of knee (TKR) and hip replacement (THR) over 13  years. 1082 community-dwelling older adults (51% women; mean age 62.9 ± 7.5 years) were studied at baseline and multiple time points over 13 years. The incidence of TKR and THR was determined by data linkage to National Joint Replacement Registry. Appendicular lean and fat mass were measure d using DXA. Lower-limb muscle strength (LMS) was assessed by dynamometer. Low muscle mass and strength were defined as the lowest sex-specific tertiles for appendicular lean mass (adjusted for height and total body fat mass) and lower-limb strength, respectively. Obesity was defined as the highest sex-specific tertile for total body fat mass. Competing risk regression models were used to estimate the sub-distribution hazard ratio (SHR) for TKR and THR. Over 13 years of follow-up, 6.8% (n = 74/1082) of the participants had a TKR and 4.7% (n = 50/1066) had THR. Participants with the combination of obesity and low muscle strength (SHR   3.36, 95% CI 1.50, 7.53) but low muscle mass (SHR 1.11, 95% CI 0.52, 2.40) had a significantly increased risk of TKR, compared to individuals with neither obesity nor low muscle mass/strength. However, obesity with low muscle strength did not lead to a significantly greater risk of TKR compare...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research

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Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
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Source: Skeletal Radiology - Category: Radiology Source Type: research
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Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
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Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
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Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
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Source: Anesthesiology - Category: Anesthesiology Source Type: research
Condition:   Clinical Trial Interventions:   Behavioral: Family Check-Up 4 Health;   Other: Services as Usual Sponsors:   Arizona State University;   Northwestern University Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Obesity, Morbid;   Metabolic Syndrome;   Bariatric Surgery Candidate;   Postoperative Complications Interventions:   Procedure: SASI Bipartition;   Procedure: Gastric bypass Sponsor:   Aleris Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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