Tests for Coronavirus Vaccine Need This Ingredient: Horseshoe Crabs

Modern medicine still depends on this animal ’s blood to test for bacteria in vaccines. And an alternative test requires further study.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Product Tests Drugs (Pharmaceuticals) Vaccination and Immunization Coronavirus (2019-nCoV) Bacteria Biotechnology and Bioengineering Eli Lilly and Company Food and Drug Administration Lonza AG Moderna Inc Cape Cod (Mass) Europe Uni Source Type: news

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While the immune response to SARS-CoV-2 is not yet well understood, insights may be gained from studies of other coronavirus infections. Here, Sariol and Perlman review the literature on animal and human coronavirus infections and discuss the critical outstanding questions for understanding SARS-CoV-2 vaccination and protective immunity.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
Credit: United NationsBy Thalif DeenUNITED NATIONS, Jul 8 2020 (IPS) The coronavirus—which has claimed the lives of over 538,000 people and infected more than 11.6 million worldwide—has destabilized virtually every facet of human life ever since its outbreak in late December. Providing a grim economic scenario of the devastation caused by the pandemic– including rising poverty, hunger and unemployment– UN Secretary-General Antonio Guterres warned last week of the possibility of an even worse disaster: the risks of bioterrorist attacks deploying deadly germs. He said it has already shown some of the...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Armed Conflicts Featured Global Global Geopolitics Global Governance Headlines Health IPS UN: Inside the Glasshouse Peace TerraViva United Nations Source Type: news
(CNN) — A global study has found strong evidence that a new form of the coronavirus has spread from Europe to the US. The new mutation makes the virus more likely to infect people but does not seem to make them any sicker than earlier variations of the virus, an international team of researchers reported Thursday. “It is now the dominant form infecting people,” Erica Ollmann Saphire of the La Jolla Institute for Immunology and the Coronavirus Immunotherapy Consortium, who worked on the study, told CNN. “This is now the virus.” The study, published in the journal Cell, builds on some earlier wo...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Coronavirus Source Type: news
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus, as well as the spike (S) protein, nucleocapsid (N) protein, and membrane (M) protein, have been tested for vaccine development against SARS and MERS. However, these vaccine candidates might lack the induction of complete protection and have safety concerns. We then applied the Vaxign and the newly developed machine learning-based Vaxign-ML reverse vaccinology tools to pred...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Coronaviruses are a genetically highly variable family of viruses that infect vertebrates and have succeeded in infecting humans many times by overcoming the species barrier. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially appeared in China at the end of 2019, exhibits a high infectivity and pathogenicity compared to other coronaviruses. As the viral coat and other viral components are recognized as being foreign by the immune system, this can lead to initial symptoms, which are induced by the very efficiently working immune defense system via the respiratory epithel...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Abstract SUMMARYIn recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika virus, Nipah virus, and coronaviruses (CoVs). Recently, a new type of viral infection emerged in Wuhan City, China, and initial genomic sequencing data of this virus do not match with previously sequenced CoVs, suggesting a novel CoV strain (2019-nCoV), which has now been termed severe acute respiratory syndrome CoV-2 (SARS-CoV-2). Although coronavirus disease 2019 (COVID-19) is suspected to originate from an animal host (zoonotic origin) followed by human-to-human transm...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post How Deforestation Helps Deadly Viruses Jump from Animals to Humans appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Environment Global Headlines Health TerraViva United Nations Source Type: news
THURSDAY, June 25, 2020 -- Animal studies of a potential COVID-19 vaccine have been so encouraging that researchers plan to speed up testing of the vaccine in humans. Initially, the next phase of the trial was expected to begin in September, but...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
“Can I get a hug?” It’s a simple question for a simple act that’s been especially missed because of COVID-19 distancing. “Human beings need social contact,” says Dr. Eugene Beresin, executive director of The Clay Center for Young Healthy Minds at Massachusetts General Hospital, and professor of psychiatry at Harvard Medical School. “We are not hermits. We are not solo pilots. We are pack animals.” Not that it needs more promotion, but along with feeling connected, a hug has been shown to help fight off a cold and help your mood when dealing with conflict. But even as restrict...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cold and Flu Coronavirus and COVID-19 Health Risks and Prevention Safety Source Type: blogs
AbstractSevere Acute Respiratory Syndrome coronavirus 2 (SARS ‐CoV‐2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS‐CoVs and Middle East Respiratory Syndrome coronavirus (MERS‐CoVs), the detailed information a bout SARS‐CoV‐2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies, and antivirals. We applied high‐throughput protein production and structure determination pipeline at the Center for Structural Genomics of I...
Source: Protein Science - Category: Biochemistry Authors: Tags: ARTICLE Source Type: research
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