Microbial metabolomics and network analysis reveal fungistatic effect of basil (Ocimum basilicum) oil on Candida albicans

Publication date: Available online 2 June 2020Source: Journal of EthnopharmacologyAuthor(s): Qiandan Miao, Linjing Zhao, Yuting Wang, Fangjia Hao, Peipei Sun, Peng He, Yumin Liu, Jiashuai Huang, Xijian Liu, Xiaohui Liu, Guoying Deng, Hongsen Li, Lingai Li, Yingao Tang, Lixin Wang, Meiqing Feng, Wei Jia
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Authors: Shay E, Sangwan N, Padmanabhan R, Lundy S, Burkey B, Eng C Abstract The etiology of head and neck squamous cell carcinoma (HNSCC) is not fully understood. While risk factors such as positive human papilloma virus (HPV) status, smoking and tobacco use have been identified, they do not account for all cases of the disease. We aimed to characterize the bacteriome, mycobiome and mycobiome-bacteriome interactions of oral wash in HNSCC patients and to determine if they are distinct from those of the oral wash of matched non-HNSCC patients. Oral wash samples were collected from 46 individuals with HNSCC and 46 co...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
AbstractIn vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such asCandida. There are few in vivo trials using probiotics as a single treatment for acuteCandida vulvovaginitis (CV). In this open-label, proof-of-concept study, selectedLactobacillus strains were tested in women with acuteCandida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel withL. plantarum YUN-V2.0,L. pentosus YUN-V1.0 andL. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vag...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Authors: Kim DK, Park YS, Cha KJ, Jang D, Ryu S, Kim KR, Kim SH, Yoon HJ, Cho SH Abstract Objectives: Sensitization to specific inhalant allergens is a major risk factor for the development of atopic diseases, which impose a major socioeconomic burden and significantly diminish quality of life. However, patterns of inhalant allergic sensitization have yet to be precisely described. Therefore, to enhance the understanding of aeroallergens, we performed a cluster analysis of inhalant allergic sensitization using a computational model. Methods: Skin prick data were collected from 7,504 individuals. A positive skin...
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
Antimicrobial Activity of Cultivable Endophytic and Rhizosphere Fungi Associated with "Mile-a-Minute," Mikania cordata (Asteraceae). Biomed Res Int. 2020;2020:5292571 Authors: Jayatilake PL, Munasinghe H Abstract Endophytic and rhizosphere fungi are understood to be aiding the host plant to overcome a range of biotic and abiotic stresses (nutrition depletion, droughts, etc.) hence, they remain to be reservoirs of plethora of natural products with immense use. Consequently, this investigation of endophytic and rhizosphere fungi isolated from Mikania cordata (a perennial vine that is well esta...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
To compare the antifungal action of two commercially available denture cleaning agents to that of standard clinical solutions, and determine their effects on the polymethyl methacrylate (PMMA) acrylic resin de...
Source: BMC Oral Health - Category: Dentistry Authors: Tags: Research article Source Type: research
Publication date: Available online 6 July 2020Source: Case Reports in Women's HealthAuthor(s): H.M. Obermair, G. Bhagwanani, R. Caldas, H. Doyle, J. Smoleniec, A. Adno
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
by Marienela Y. Heredia, M élanie A. C. Ikeh, Deepika Gunasekaran, Karen A. Conrad, Sviatlana Filimonava, Dawn H. Marotta, Clarissa J. Nobile, Jason M. Rauceo The human fungal pathogenCandida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence. The transcription factors Sko1, Cas5, and Rlm1 control the response to cell wall stress caused by the antifungal drug caspofungin. Here, we expand the Sko1 and Rlm1 transcriptional circuit and demonstrate that Rlm1 activates Sko1 cell wall stress s...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Candida tropicalis is one the most relevant biofilm-forming fungal species increasingly associated with invasive mucosal candidiasis worldwide. The amplified antifungal resistance supports the necessity for more effective and less toxic treatment, including the use of plant-derived natural products. Scopoletin, a natural coumarin, has shown antifungal properties against plant yeast pathogens. However, the antifungal activity of this coumarin against clinically relevant fungal species such as C. tropicalis remains to be established. Here, we investigated the potential antifungal properties and mechanisms of action of scopol...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study indicated that S. mutans could help GBS integrate into the Streptococcus-associated oral polymicrobial community and become a resident species in the oral cavity, increasing the risk of oral infections.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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