Bioactivities of 7 & #39;-ethoxy-trans-feruloyltyramine from Portulaca oleracea L. and its metabolism in rats using ultra-high-performance liquid chromatography electrospray coupled with quadrupole time-of-flight mass spectrometry

Zheming Ying, Mingyue Jiang, Lina Wang, Xixiang Ying, Guanlin YangIndian Journal of Pharmacology 2020 52(2):130-133 This research aims to study the antioxidation and anticholinesterase activities of 7'-ethoxy-trans-feruloyltyramine (ETFT), which was an alkaloid isolated from Portulaca oleracea for the first time. Furthermore, its main metabolites and metabolic pathways in rats were also explored. The antioxidation and anticholinesterase effects of ETFT were, respectively, examined using 1,1-diphenyl-2-picrylhydrazyl assay and modified Ellman's method. The results showed that ETFT exhibited both the good antioxidant and anticholinesterase effects. Its main metabolites in rats were implemented, and nine metabolites were finally found in the rat's plasma and urine, including the oxidation, reduction, hydrolysis, glucuronidation, sulfation, and glutathionylation process.
Source: Indian Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research