Exercise and browning of white adipose tissue - a translational perspective.

Exercise and browning of white adipose tissue - a translational perspective.
Curr Opin Pharmacol. 2020 May 28;52:18-24
Authors: Severinsen MCK, Schéele C, Pedersen BK
Abstract
Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.
PMID: 32480032 [PubMed - as supplied by publisher]

Source: Current Opinion in Pharmacology - May 27, 2020 Category: Drugs & Pharmacology Authors: Severinsen MCK, Schéele C, Pedersen BK Tags: Curr Opin Pharmacol Source Type: research