Assessing the need for routine safety testing for patients being treated with dupilumab for moderate-to-severe atopic dermatitis.

Assessing the need for routine safety testing for patients being treated with dupilumab for moderate-to-severe atopic dermatitis. Br J Dermatol. 2020 Jun;182(6):e186-e209 Authors: Wollenberg A, Beck LA, Blauvelt A, Simpson EL, Chen Z, Chen Q, Shumel B, Khokhar FA, Hultsch T, Rizova E, Rossi AB, Graham NMH, Pirozzi G, Lu Y, Ardeleanu M Abstract Atopic dermatitis (also known as AD or eczema) is a common skin disease that can cause intense and persistent itching and rashes. Skin creams or ointments are not suitable or effective for some patients with moderate-to-severe AD. In these patients, oral (taken by mouth) or injected medications may be required. Some of those oral or injected treatments could be toxic and often have unwanted side effects, especially when used for a longer period of time, so patients must be regularly tested to see whether those treatments are harming their blood or organs. Dupilumab is a newer injectable drug for treating moderate-to-severe AD. Dupilumab specifically targets key molecules in the body that cause AD. Dupilumab has been tested for up to one year in more than 2000 patients enroled in placebo-controlled clinical trials. During those trials, patients provided blood and urine samples for laboratory testing while they were being treated with dupilumab or placebo (dummy drug). In this paper, the authors from Germany and the U.S.A, analysed how blood cells, blood chemistry, and urine chemistry changed during treatment, to che...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
A 15-year-old boy presented to clinic due to concern over the loss of hair in both eyebrows. Over the past 6 months, his pre-existing atopic dermatitis had progressively flared, but he was not receiving treatment. In addition to severe facial and flexural eczema, he had prominent rarefaction of the lateral one-third of both eyebrows, a finding known as Hertoghe ’s sign (Figure, A).1 The patient denied eyebrow plucking or rubbing. Laboratory tests showed eosinophilia (1070 cells/mm3), normal thyroid function, and negative syphilis testing.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Rediscovering the Physical Exam Source Type: research
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Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
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Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conditions:   Nickel; Eczema;   Nickel Sensitivity;   Allergy;   Inflammatory Response Intervention:   Other: Nickel sulfate hexahydrate Sponsors:   National Allergy Research Center, Denmark;   University of Copenhagen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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