Molecules, Vol. 25, Pages 2595: Anti-Tumor Effects of Biomimetic Sulfated Glycosaminoglycans on Lung Adenocarcinoma Cells in 2D and 3D In Vitro Models

In conclusion, GAG-mimetic AlgSulf with increased DS exhibit enhanced anti-proliferative and migratory properties while also reducing growth of KRAS-mutant LUAD spheres in vitro. We suggest that these anti-tumor effects by GAG-mimetic AlgSulf are possibly due to differential binding to GFs and consequential decreased cell stemness. AlgSulf may be suitable for applications in cancer therapy after further in vivo validation.

Source: Molecules - June 2, 2020 Category: Chemistry Authors: Nada Al Matari George Deeb Hiba Mshiek Ansam Sinjab Humam Kadara Wassim Abou-Kheir Rami Mhanna Tags: Article Source Type: research