Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells
Publication date: Available online 1 June 2020Source: Pathology - Research and PracticeAuthor(s): Zhi-Yun Zhang, Meng Lu, Ze-Kun Liu, Hao Li, Yu-Le Yong, Ren-Yu Zhang, Zhi-Nan Chen, Huijie Bian
Authors: Han S, Kim DY PMID: 32646205 [PubMed - in process]
Conclusions: The serum levels of myostatin, follistatin, and IL-6 and their correlation with sarcopenia and survival were presented in HCC patients for the first time. The role of the serum follistatin level as a poor prognostic biomarker warrants further study. PMID: 32646201 [PubMed - as supplied by publisher]
Conclusions: SBRT showed excellent results as an ablative treatment for patients with small HCCs while showing minimal toxicities. SBRT can be a good alternative for both curative and salvage intents in patients with HCCs that are unsuitable for curative treatments. PMID: 32646200 [PubMed - as supplied by publisher]
Publication date: Available online 10 July 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yan Zhao, Ya-Ni Zhang, Kai-Ting Wang, Lei Chen
Publication date: Available online 11 July 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Paola Dongiovanni, Marica Meroni, Salvatore Petta, Miriam Longo, Anna Alisi, Giorgio Soardo, Luca Valenti, Luca Miele, Stefania Grimaudo, Grazia Pennisi, Grieco Antonio, Dario Consonni, Silvia Fargion, Anna Ludovica Fracanzani
CONCLUSIONS: Our initial results of active scanning PT for primary liver cancer demonstrated the feasibility, safety, and effectiveness of this advanced technique in this setting. The potential of the combination of PT with other locoregional therapies is under evaluation. PMID: 32648818 [PubMed - as supplied by publisher]
Publication date: Available online 11 July 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Tsung-Hao Liu, Yu-Yun Shao, Chih-Hung Hsu
In this study, 1452 patients were enrolled. Independent risk factors for recurrence-free survival (RFS) and overall survival (OS) were analyzed for patients with and without CSPH. For HCC patients without CSPH, multivariate analysis suggested that microvascular invasion (MVI), neutrophil-to-lymphocyte ratio (NLR) ≥ 3, platelet-to-lymphocyte ratio (PLR) ≥ 150, tumor size> 5 cm, and the presence of a satellite lesion were independently associated with RFS. MVI, NLR ≥ 3, PLR ≥ 150, and advanced Barcelona clinical liver cancer (BCLC) stage contributed to mortality. However, neither NLR nor PLR showed any prognos...
Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are both reversible processes, and regulation of phenotypical transition is very important for progression of several c...