Review: Role of cAMP signaling in diabetic retinopathy.

Review: Role of cAMP signaling in diabetic retinopathy. Mol Vis. 2020;26:355-358 Authors: Steinle JJ Abstract Despite decades of research, diabetic retinopathy remains the leading cause of blindness in working age adults. Treatments for early phases for the disease remain elusive. One pathway that appears to regulate neuronal, vascular, and inflammatory components of diabetic retinopathy is the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. In this review, we discuss the current literature on cAMP actions on the retina, with a focus on neurovascular changes commonly associated with preproliferative diabetic retinopathy models. PMID: 32476815 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research

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In conclusion, this study highlights the negative role of miR-221-3p in the microvascular dysfunction in diabetic retinopathy by targeting TIMP3, representing a potential therapeutic target for human diabetic retinopathy. PMID: 32648125 [PubMed - as supplied by publisher]
Source: Pflugers Archiv : European Journal of Physiology - Category: Physiology Authors: Tags: Pflugers Arch Source Type: research
Preliminary research on the effects and mechanisms of umbilical cord‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy. Int J Mol Med. 2020 Aug;46(2):849-858 Authors: Zhao K, Liu J, Dong G, Xia H, Wang P, Xiao X, Chen Z Abstract Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of diabetes, and a common cause of blindness in working‑age individuals. Mesenchymal stem cell (MSC) transplantation has been considered a promising intervention therapy for DR, wherein the differentiation of MSCs into nerve cells plays an essential role. Howeve...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
AbstractSummaryThe risks for hip fracture and vertebral fracture, but not the risk for distal radius fracture, were significantly higher in the blindness group than in the control group with a maximum 12-year follow-up.PurposeTo evaluate the influence of visual impairment on the risk for osteoporotic fractures at common sites: hip, thoracic/lumbar vertebra, and distal radius.MethodsThis longitudinal follow-up study used a database of a national sample cohort from 2002 to 2013 provided by the Korean National Health Insurance Service. Of a total of 1,125,691 subjects, 3918 patients with visual impairment and age ≥ 50 year...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
CONCLUSION: MiR-199a-3p upregulation ameliorated HG-stimulated angiogenesis of hRMECs by modulating the PI3K/AKT pathway through inhibiting VEGF. Although retinal neovascularization in vivo has not been studied, these in vitro findings provide more evidence for the role of miR-199a-3p upregulation against HG-induced angiogenesis. PMID: 32622012 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
We present a case of bilateral occipito-temporal infarction revealed by a sudden cortical blindness with haemorrhagic transformation after intravenous thrombolysis in a diabetic patient infected by Covid-19. Differential diagnoses are discussed in front of this unusual presentation and evolution.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Case Report Source Type: research
Abstract Diabetic retinopathy (DR) is one of the major causes of visual impairment and blindness worldwide. The onset and progression of DR are influenced by systemic factors such as hyperglycemia and hypertension as well as ocular parameters. A better knowledge of the risk factors for DR is vital to improving the outcome of patients with DR and risk stratification. More recently, there has been increasing focus on the influence of myopia on DR development. Some observational studies have reported myopia being a protective factor for the development of DR, however the findings were inconsistent. In addition, it re...
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
Sure, if something’s portable, easy to use and helps patients and doctors alike, it definitely ticks all our boxes. Does that mean we are going to test it though? Who are we kidding, of course it does! Join us on our journey to learn about the present and future of ophthalmology – and to get to know D-EYE, a new handheld digital retinal camera. Ophthalmology can really profit from telemedicine. Recognising its potential, tech companies started targeting this medical sector, producing more and more interesting apps and devices. So, naturally, we’ve kept our eyes on ophthalmology for the past couple of y...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Healthcare Design Medical Education Robotics Science Fiction Telemedicine & Smartphones review ophthalmology eye test d-eye Source Type: blogs
Type 2 Diabetes Mellitus (T2DM) prevention is a worldwide health care priority (1), with levels of prediabetes predicted to rise from 374 million in 2019 to 548 million by 2045 (1). This is increasingly important as levels of obesity and physical inactivity being major contributory factors towards the global diabetes burden, are escalating (1,2). Although T2DM directly leads to approximately 1.3 million deaths annually (worldwide), it is a major risk factor for other causes of death and conditions such as cardiovascular disease, kidney diseases and blindness (3).
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Review Source Type: research
Abstract AIMS: Diabetes-induced retinal vascular cell death aggravates diabetic retinopathy (DR) to the proliferative stage and blindness. Pericytes play a crucial role in retinal capillaries survival, stability, and angiogenesis. Ephrin-B2 is a tyrosine kinase that regulates pericytes/endothelial cells communication during angiogenesis; yet, its role in DR is still unclear. We hypothesize that diabetes increases Ephrin-B2 signaling in pericytes, which contributes to inflammation and retinal vascular cell death. METHODS: Selective inhibition of the Ephrin-B2 expression in the retinal pericytes was achieved us...
Source: Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Vascul Pharmacol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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