Protective effects of cardiac resynchronization therapy in a canine model with experimental heart failure by improving mitochondrial function: a mitochondrial proteomics study
ConclusionsCRT treatment significantly improved cardiac function, reduced myocardial fibrosis, and enhanced mitochondrial function in the failing heart through CAPN1 downregulation.
Patients with a systemic right ventricle (SRV) are at high risk for development of heart failure early in life. An SRV is encountered in patients with congenitally corrected transposition of the great arteries (CCTGA) or dextro-transposition of the great arteries (DTGA) with previous atrial switch repair (Mustard or Senning procedure). Progressive heart failure is one of the leading cause of mortality in these patients. Therefore, cardiac resynchronization therapy (CRT) has gained increasing momentum for use in this challenging congenital heart disease (CHD) population.
AbstractBackgroundHis bundle pacing (HBP) has evolved as the most physiological form of pacing but associated with limitations. Recently, left bundle branch pacing (LBBP) is emerging as an effective alternative strategy for HBP.ObjectivesOur study was designed to assess the feasibility, efficacy, electrophysiological parameters, and mid-term outcomes of LBBP in Indian population.MethodsAll patients requiring permanent pacemaker implantation for symptomatic bradycardia and heart failure were prospectively enrolled. Echocardiography, QRS duration, pacing parameters, left bundle (LB) potentials, paced QRS duration, and peak l...
His bundle pacing (HBP) and left bundle pacing (LBP) are emerging as novel delivery methods for cardiac resynchronisation therapy (CRT) in heart failure patients with left bundle branch block (LBBB). HBP and LBP have never been compared to biventricular endocardial (BiV-endo) pacing. Furthermore, there are indications of negative effects of LBP on right ventricular (RV) activation times (ATs), but these effects have not been quantified.
Background: We aimed to characterize the hourly, daily, and seasonally variations in the detection of new atrial fibrillation (AF) in heart failure (HF) patients implanted with a defibrillator.MethodsIn 1309 patients enrolled in MADIT ‐RIT without AF at baseline, atrial arrhythmia data were analyzed from device interrogations. The circadian, weekly and seasonal distribution of device detected AF was evaluated. The morning period was defined as 06:00‐11:59, afternoon as 12:00‐16:59, evening as 17:00‐22:59, and the nighttim e as 23:00‐05:59.Results: During 17 months of follow ‐up, 66 (5%) patients developed new d...
Clinicians lack reliable methods to predict which patients with congestive heart failure (CHF) will benefit from cardiac resynchronization therapy (CRT). Symptom burden may help to predict response, but this information is buried in free-text clinical notes. Natural language processing (NLP) may identify symptoms recorded in the electronic health record (EHR) and thereby enable this information to inform clinical decisions about the appropriateness of CRT.
Clinicians lack reliable methods to predict which patients with congestive heart failure (CHF) will benefit from cardiac resynchronization therapy (CRT). Symptom burden possibly predicts response, but this information is buried in free-text clinical notes. Artificial intelligence (AI) tools to identify symptoms in the electronic health record (EHR) may allow for the structured inclusion of these data into pre-procedural decision-making.
This study aimed to determine if changes in myeloperoxidase (MPO) levels correlate with response to cardiac resynchronization therapy (CRT) and the potential role of MPO as a predictor of response to CRT.BackgroundCRT is a well-established treatment option in chronic heart failure (CHF) with 50 –80% of patients benefiting. Inflammation and oxidative stress play a key role in CHF pathophysiology. Previous studies have demonstrated increased levels of MPO in CHF patients, but the correlation with CRT response remains incompletely understood.Methods Fifty-three patients underwent CRT implantation. During follow-up, pati...
We present a complex case with successful, high ‐density electroanatomic mapping (EAM) guided corrective His bundle pacing (CHBP) following failed CRT upgrade in a patient with PLSVC, congenital heart disease, and pacing‐associated heart failure. CHBP restored physiological conduction in left bundle branch block with complete conduction block leading to clinical improvement and cardiac remodeling. The presented case supports the growing evidence that EAM‐guided CHBP may be considered a feasible alternative to conventional CRT when venous anatomy is not favorable for left ventricular lead implantation.
Functional tricuspid regurgitation (TR) caused by remodeling of the tricuspid valve (TV) accompanied by right ventricular (RV) and right atrial remodeling is the most common cause of significant TR in patients with cardiac diseases.1-3 In contrast, the number of patients who have received cardiac implantable electronic devices (CIED) including a permanent pacemaker (PM), implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy (CRT) device has been increased in patients with advanced cardiac diseases.
Functional tricuspid regurgitation (TR) caused by remodeling of the tricuspid valve (TV) accompanied by right ventricular (RV) and right atrial remodeling is the most common cause of significant TR in patients with cardiac diseases.1 –3 In contrast, the number of patients who have received cardiac implantable electronic devices (CIED) including a permanent pacemaker (PM), implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy (CRT) device has been increased in patients with advanced cardiac diseases .