Frequency of heterozygous germline pathogenic variants in genes for Fanconi anemia in patients with non- BRCA1/BRCA2 breast cancer: a meta-analysis

ConclusionsHeterozygous pathogenic variants inFANCN/PALB2 and possiblyFANCJ/BRIP1 may account for 1 –2% of familial non-BRCA1/2 breast cancer cases and 0.5–1% of unselected cases. Genetic counseling and testing may be suggested for unaffected relatives.

Source: Breast Cancer Research and Treatment - June 1, 2020 Category: Cancer & Oncology Source Type: research