Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons.

Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons.
Cell Mol Life Sci. 2020 May 31;:
Authors: Marlier Q, D'aes T, Verteneuil S, Vandenbosch R, Malgrange B
Abstract
A persistent dogma in neuroscience supported the idea that terminally differentiated neurons permanently withdraw from the cell cycle. However, since the late 1990s, several studies have shown that cell cycle proteins are expressed in post-mitotic neurons under physiological conditions, indicating that the cell cycle machinery is not restricted to proliferating cells. Moreover, many studies have highlighted a clear link between cell cycle-related proteins and neurological disorders, particularly relating to apoptosis-induced neuronal death. Indeed, cell cycle-related proteins can be upregulated or overactivated in post-mitotic neurons in case of acute or degenerative central nervous system disease. Given the considerable lack of effective treatments for age-related neurological disorders, new therapeutic approaches targeting the cell cycle machinery might thus be considered. This review aims at summarizing current knowledge about the role of the cell cycle machinery in post-mitotic neurons in healthy and pathological conditions.
PMID: 32476056 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - May 30, 2020 Category: Cytology Authors: Marlier Q, D'aes T, Verteneuil S, Vandenbosch R, Malgrange B Tags: Cell Mol Life Sci Source Type: research