Development of a human in vitro blood –brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance

ConclusionsThis original human BBTB model allows a better understanding of the influence of DIPG on the BBTB ECs phenotype. Our data reveal that the chemoresistance described for DIPG does not come from the development of a “super BBB”. These results, validated by the absence of modification of drug transport through the BBTB ECs, point out the importance of understanding the implication of the different protagonists in the pathology to have a chance to significantly improve treatment efficiency.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research