Evaluation of Genotoxicity of Perchlozone, Antituberculous Drug

Experimental studies of Perchlozone, an antituberculous drug with manifest inhibitory activity towardsMycobacterium tuberculosis andMycobacterium bovis, were carried out. Genotoxicity of Perchlozone was evaluated by the DNA comet method on liver and lung tissues and blood cells after 14-day inhalation exposure of rats. The level of DNA aberrations in response to inhalations of the drug in a concentration of 102.6 ±13.7 mg/m3 increased in lung tissue but not in the blood cells or liver. These results indicated genotoxic activity of antituberculous drug Perchlozone.
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research