Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis

ConclusionWe performed quantitative comparative proteomic analysis using by LC –MS/MS of the SF from four disease states: RA, gout, and OA. This systematic comparison revealed novel differentially expressed proteins in AS SF, as well as two previously reported candidate biomarkers. We further verified the expression of MMP3, C9 and CFHR5 by western blot. These proteins may s erve as diagnostic or prognostic biomarkers in patients with AS, and may thus improve the clinical outcomes of this serious disease.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research