CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis [Immunology and Inflammation]

Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated host response to an infection. Here we report that the circulating levels of growth and differentiation factor-15 (GDF15) are strongly increased in septic shock patients and correlate with mortality. In mice, we find that peptidoglycan is a potent ligand...

Source: Proceedings of the National Academy of Sciences - June 1, 2020 Category: Science Authors: Isa Santos, Henrique G. Colaco, Ana Neves–Costa, Elsa Seixas, Tiago R. Velho, Dora Pedroso, Andre Barros, Rui Martins, Nuno Carvalho, Didier Payen, Sebastian Weis, Hyon–Seung Yi, Minho Shong, Luis F. Moita Tags: Biological Sciences Source Type: research