New guidelines for assessment of bone density and microarchitecture in vivo with HR-pQCT

(International Osteoporosis Foundation) There is an urgent need for guidance and consensus on the methods for, and reporting of, high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging so that different studies can be compared to each other. This position paper, published by a joint working group from IOF, ASBMR and ECTS addresses the need for standardization of techniques and terminology, provides guidance on interpretation and reporting of results, and discusses unresolved issues in the field.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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AbstractSummaryOpportunistic osteoporosis screening involves measuring the attenuation of L1 vertebrae on abdominal computed tomography (CT), which correlates with DXA T-score. We found that this approach is useful for detecting low bone mass in patients with diabetes and propose L1 attenuation ≤ 135 Hounsfield units (HU) as a threshold for which DXA should be strongly considered.IntroductionAttenuation of the L1 vertebrae on computer tomography (CT) images done for other reasons ( “Opportunistic Osteoporosis Screening”) has been found to correlate well with DXA-derived T-score. However, the method an...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractSummaryThere is limited evidence regarding changes in bone microstructure in patients with hypoparathyroidism. In the current study, we used a non-invasive technique to assess bone structure in hypoparathyroidism patients and discovered site-specific changes which were mainly influenced by age and menstrual status. Such changes were more prominent in the trabeculae as well as in non-surgical as opposed to post-surgical patients.IntroductionHypoparathyroidism (hypoPT) is a rare disease characterized by the lack of parathyroid hormone. There is limited evidence regarding changes in bone microstructure in patients wit...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Theaflavin-3, 3′-digallate (TF3) is extracted from black tea and has strong antioxidant capabilities. The aim of this study was to assess the influences of TF3 on osteoclastogenesis and explore the underlying mechanisms. TF3 efficiently decreased receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast formation and reactive oxygen species (ROS) generation in a dose-dependent manner. Mechanistically, TF3 reduced ROS generation by activating nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream heme oxygenase-1 (HO-1) and also inhibited the mitogen-activated protein kinases (MAPK)...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Conclusion. In M-LIF, there were no significant differences in bone fusion score between WT- and BP-treated patients. In contrast, BC status immediately postoperatively had a major impact on 6-month bone fusion. Level of Evidence: 1
Source: Spine - Category: Orthopaedics Tags: RANDOMIZED TRIAL Source Type: research
ConclusionsThe study identified that entropy and uniformity are a relevant parameters data in bone fragility assessment in acromegalic patients.
Source: Endocrine - Category: Endocrinology Source Type: research
AbstractPrimary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia in the clinical setting and affects 0.3% of the population. Parathyroidectomy is the only definitive cure. Unfortunately, even in the most experienced hands, persistent primary hyperparathyroidism (P-PHPT) occurs in 4.7% of the patients. Ectopic adenomas are difficult to localize before and during operation and usually end up with P-PHPT. Herein, we presented a case with P-PHPT due to mediastinal parathyroid adenoma that was successfully ablated with selective arterial embolization. A 57-year-old female patient was admitted to our endocrin...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This study aimed to investigate the following: (1) the effect of the exercise program on paraspinal and psoas (back) muscle CSA and VAT, and 2) if any exercise-related changes in muscle CSA and/or VAT were associated with changes in spinal BMD.MethodsMen (n = 180) aged 50 –79 years were randomized to an exercise or no-exercise group. Exercise involved high-intensity progressive resistance training (60–85% max) with weight-bearing impact exercise (3 days/week) for 18 months. Quantitative computed tomography was used to assess L1–L3 Tb.vBMD, paraspinal, and psoas muscle CSA and VAT.ResultsExercise resulted ...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
CONCLUSION: The results revealed that CAG alleviates age-related bone loss and improves bone microstructure and biomechanical properties. This may due to CAG-induced increase in OA expression. In addition, the results support preclinical investigations of CAG as a potential therapeutic medicine for the treatment of senile osteoporosis. PMID: 32497865 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
We present a 36-year-old man initially presenting with diffuse bone and joint pain who was inappropriately treated for presumed ankylosing spondylitis for 2 years. Whole-body bone scan suggested metabolic bone disease, prompting referral to our endocrine institution. He was subsequently diagnosed with persistent hypophosphataemia, inappropriately high renal tubular phosphate excretion, 1,25-dihydroxyvitamin D3 suppression, severe osteoporosis and severe osteomalacia. FGF-23 concentrations (140 ng/L) were raised 3-fold above the upper limit of normal. Initial Gallium-68 (68Ga) DOTATATE positron emission tomography...
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Bone Rep Source Type: research
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