Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients. Correlation with IVF parameters.

Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients. Correlation with IVF parameters. Biochem Cell Biol. 2020 May 31;: Authors: Massa E, Pelusa F, Lo Celso A, Madariaga MJ, Filocco L, Morente C, Ghersevich SA Abstract Since our previous results suggest that LF might have roles in the reproductive process and its levels might change in the female tract as a response to various factors, the aim of this investigation was to assess whether LF levels in cervical secretions correlate with reproductive parameters from in vitro fertilization (IVF) patients. Cervical fluid samples were obtained from 34 women under 40 years old enrolled for assisted reproduction techniques and LF concentration was measured. The mean total protein concentration in all cervical fluid samples was 842.8±116.9 µg/ml. The mean concentration of LF was 0.73±0.06 ng LF/µg of total proteins. We observed that higher LF levels in cervical fluid correlated with lower IVF rates when all patients were analyzed; and this negative correlation was also sustained when only patients ≥35 years were studied. The mean LF concentration in cervical fluid was significantly lower among patients with normal IVF rates than in those with values ≤50%. Using a LF cutoff value of 0.83 ng LF/μg total proteins, the study revealed a significant association between the LF levels <0.83 ng LF/µg total proteins and IVF rates >50%. LF levels in cervical muc...
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research