Trump-Touted Hydroxychloroquine in Short Supply for Lupus Patients

TUESDAY, June 2, 2020 -- A drug championed by President Donald Trump as a coronavirus panacea appears to be in short supply for people who really need it: lupus patients. More than one-third of U.S. lupus patients who take hydroxychloroquine have...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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We present a case of severe refractory thrombocytopenia in a 51-year-old woman with a history of long-standing systemic lupus erythematosus and antiphospholipid syndrome who presented with hemoptysis in the setting of COVID-19 infection. The patient failed to respond to initial treatment with intravenous immunoglobulin, high-dose steroids, and platelet transfusion, but responded to eltrombopag, with prompt improvement of a platelet count. The current case report provides clinical data of relevance to the largely unexplored question of the immunologic complications of COVID-19 in patients with a pre-existing inflammatory st...
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
Coronavirus disease 2019 (COVID-19) patients are at high risk of thrombosis related to endothelium injury, low blood flow and marked hypercoagulability [1]. Recently, a high prevalence of lupus anticoagulant (LA) was reported in the COVID-19 patients [2], immediately questioned by the possibility of false positive testing given the marked elevation in C-reactive protein (CRP) levels attributed to the major pulmonary or systemic inflammation in these patients [3]. Interestingly, a strong association between thrombosis and the presence of LA in critically ill COVID-19 was suggested but not demonstrated [4].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds were used as antimalarial agents for many years. Currently, they are used as monotherapy or in conjunction with other therapies for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS) and antiphospholipid antibody syndrome (APS). Based on its effects on the modulation of the autophagy process, various clinical studies suggest that CQ and HCQ could be used in combination with other chemo...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
On June 3, the World Health Organization (WHO) resumed a study looking into whether the malaria drug hydroxychloroquine could be effective in treating COVID-19. Last week, the WHO temporarily stopped people from enrolling in the trial, part of a larger study called Solidarity that is investigating a number of different potential coronavirus therapies, over concerns about the hydroxychloroquine’s adverse effects on the heart. That followed the publication of a Lancet study on May 22, involving more than 96,000 people, which found that the drug did not improve survival among patients hospitalized with COVID-19, and tha...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
AbstractObjectivesPrimary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure.Secondary objectives:To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial.To evaluate the duration of COVID-19 symptoms in participants receiving melatonin before the infection...
Source: Trials - Category: Research Source Type: clinical trials
TUESDAY, June 2, 2020 -- A drug championed by President Donald Trump as a coronavirus panacea appears to be in short supply for people who really need it: lupus patients. More than one-third of U.S. lupus patients who take hydroxychloroquine have...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Abstract We thank So for the interest in our letter and for sharing the results about COVID-19 in patients with systemic lupus erythematosus (SLE) in Hong Kong (1). We agree that the quantification of the risk of infection with severe acute respiratory coronaviruses- 2 (SARS-CoV-2) in SLE patients is a major concern. PMID: 32482654 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
BOSTON (CBS) —  As Massachusetts continues to fight the coronavirus pandemic, the public has plenty of questions. Dr. Mallika Marshall answered some of those sent to her email (drmallika@cbs.com) and Facebook and Twitter accounts. “Is it true that if someone tested positive for COVID-19 that they will always test positive because they have the antibody in them?” –Lina There are two main tests right now. One is a swab in the nose that looks for the actual virus in the body. The other is a blood test that looks for antibodies to the virus. Once the virus is gone from the body,...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Seen On WBZ-TV Syndicated Local Coronavirus Dr. Mallika Marshall Source Type: news
The healing power of ultraviolet light (UV) has flown under the radar for decades. Yet, it’s one of the most powerful detoxifying agents known to man. It kills bacteria and viruses and can be used in a clinical setting. The therapeutic benefits of light have been known for millennia. Hippocrates, the father of modern medicine, believed light was essential to balance the body and emotions. And there is good reason why, during the Spanish flu pandemic of 1918, medics discovered that severely ill patients had hugely better recovery rates when they were nursed outside and had regular exposure to sunlight.1 You see, UV r...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
(WASHINGTON) — President Donald Trump emphatically defended himself Tuesday against criticism from medical experts that his announced use of a malaria drug against the coronavirus could spark wide misuse by Americans of the unproven treatment with potentially fatal side effects. Trump’s revelation a day earlier that he was taking hydroxychloroquine caught many in his administration by surprise and set off an urgent effort by officials to justify his action. But their attempt to address the concerns of health professionals was undercut by the president himself. He asserted without evidence that a study raising a...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Donald Trump News Desk wire Source Type: news
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