1185 comparing right colon adenoma and hyperplastic polyp miss rates in colonoscopy using water exchange and carbon dioxide insufflation: a randomized controlled tandem study

We reported retrospective data that compared with CO2 insufflation, water exchange (WE) colonoscopy significantly reduced rAMR (17.5% vs. 33.8%, P=0.034) (BMC Gastroenterol 2019;19:143). We performed a prospective randomized controlled trial (RCT) of WE and CO2 insufflation to determine whether WE with near-complete removal of infused water during insertion could reduce rAMR and rAMR combined with right colon hyperplastic polyp miss rate (rHPMR).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research

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Endoscopic submucosal dissection (ESD) allows en bloc removal of colon polyps and early colon cancer. Multiple studies have demonstrated the advantages of ESD versus endoscopic mucosal resection (EMR). However, ESD is technically difficult, labor-intensive and time-consuming. We performed a single center, retrospective observational study to evaluate safety and effectiveness of a new endoluminal double balloon interventional platform (Lumendi LLC, Westport, CT) for colonic polyp resection.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research
Endosc Int Open 2020; 08: E628-E635 DOI: 10.1055/a-1119-6509 Background and study aims Multiple neoplasia increase the risk of colorectal cancer. High-quality cleansing may improve adenoma detection. We assessed whether a new bowel preparation can improve colon cleansing and multiple lesion detection. Patients and methods This post hoc analysis of two randomized clinical trials in Europe and the US assessed the per study and combined cleansing efficacy of overnight split dosing with (preparation + clear fluids) 1 + 1 L polyethylene glycol (PEG) NER1006 versus 2 + 1 L PEG + ascorbate (2LP...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer.MethodsCelecoxib oral suspension (40 mg/kg BID) was dosed to Apc-mutant Pirc (F344/NTac-Apcam1137) rats for 4 days (short-term group), or the equivalent dose of 1500 ppm celecoxib was administered in the diet for 4 months (long-term group). Percent inhibition of colonic PGE2 was calculated, and the reduction in colonic PGE2 was assessed in relation to suppression of adenomatous colon polyps.ResultsColonic mucosa PGE2 was fourfold higher...
Source: Inflammation Research - Category: Research Source Type: research
This study evaluates the effectiveness of laparoscopic TAP blocks in conjunction with the benefit of an ERP. One hundred thirty-seven consecutive laparoscopic and robotic-assisted Colorectal Surgery patients received TAP blocks under laparoscopic guidance while under anesthesia, randomized to a placebo, bupivacaine TAP block, or bupivacaine TAP block with an ERP arm of the trial. Patient demographics, operative techniques, and postoperative outcomes were analyzed using statistical analysis software. Our main objective was to determine short-term benefits of TAP blocks on reducing total narcotic consumption. Secondary objec...
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
With more colorectal cancer screening&large polyp removal, delayed post-polypectomy ulcer bleeds (PPUB) are increasing. Risk factors are right colon, sessile configuration, EMR removal, bleeding during polypectomy,&resumption of anti-coagulants&/or dual anti-platelet drugs. Prophylactic clip closure of PPU ’s is reported to be safe but does not reduce delayed PPUB nor is it cost effective. In our studies of patients hospitalized with delayed PPUB, all had ulcers, most with stigmata&arterial blood flow detected by Doppler endoscopic probe (DEP).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
Incomplete resection of colorectal neoplasia decreases the efficacy of colonoscopy and contributes to post-colonoscopy colorectal cancer. Conventional endoscopic resection (CR) of polyps, performed in a gas-distended colon, is the current standard, but incomplete resection rates (IRR) of approximately 3-25% for non-diminutive (>5mm) non-pedunculated lesions are reported. Underwater endoscopic resection (UR), a novel technique utilizing advantages of water-aided colonoscopy, may help reduce IRR.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
Cosmeri Rizzato1, Javier Torres2, Elena Kasamatsu3, Margarita Camorlinga-Ponce2, Maria Mercedes Bravo4, Federico Canzian5 and Ikuko Kato6* 1Department of Translation Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy 2Unidad de Investigación en Enfermedades Infecciosas, Unidades Médicas de Alta Especialidad Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico 3Instituto de Investigaciones en Ciencias de la Salud, National University of Asunción, Asunción, Paraguay 4Grupo de Investigación en Biología del C&aacut...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions The current review reports recent epidemiological and experimental data supporting the bright future of dietary polyphenols as chemopreventive, anti-inflammatory, immunomodulatory, and anticancer agents in CRC (Figure 1). The polyphenol-rich diet not only may represent a chemopreventive treatment but also has important function on immune system by promoting symbiont and commensal bacterial populations, increases reciprocal interaction between host and microbiota which in turn have important effects on immune function Evidence underlines the use of polyphenols as sensitizers of chemo/radiotherapies paving the w...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
RESUMEN: La Poliposis Adenomatosa Familiar (PAF) es un s índrome hereditario autosómico dominante causado por la mutación del gen APC. En su forma clásica se desarrollan más de 100 pólipos adenomatosos intestinales que progresan a cáncer colorrectal en casi el 100% de los casos no tratados. Dentro de las manifestaciones extracolónicas de PAF, se e ncuentran las maxilofaciales, como: osteomas y alteraciones dentales, que pueden preceder por años al desarrollo de poliposis colónica. A pesar de que en Chile hay estudios de PAF y cáncer de colon, son ...
Source: Revista clinica de periodoncia, implantologia y rehabilitacion oral - Category: Dentistry Source Type: research
Purpose of review Colonoscopy is recognizably, the best colon cancer prevention test, provided the quality of the preparation is adequate for detection of precancerous polyps but also allowing for accurate identification of margins, thereby facilitating complete endoscopic resection. As there are many aspects effecting colon prep outcomes, it is timely to review new standards for optimizing outcomes, including product selection based on patient demographics. Recent findings New national guidelines have set a minimum quality threshold for adequacy and also defined a split day delivery for oral options as the “sta...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: LARGE INTESTINE: Edited by Eamonn M.M. Quigley Source Type: research
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