Sa2035 LONG-TERM FOLLOW-UP OF ADVANCED COLON POLYPS REMOVED USING ENDOSCOPIC MUCOSAL STRIPPING (EMS)

Postpolypectomy bleeding and incomplete polyp removal are important complication and quality concerns of colonoscopy for colon cancer prevention. Endoscopic mucosal stripping (EMS) is a modified extension of traditional cold snare polypectomy to avoid submucosal injury during removal of non-pedunculated colon polyps. We previously demonstrated EMS could potentially eliminate postpolypectomy bleeding, especially for advanced colon polyps, and facilitate complete polyp removal based on polypectomy site biopsy and short-term follow-up colonoscopy (1,2).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research

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Colonoscopic removal of adenomatous polyps has a preventive effect for colorectal cancer. Cold snare polypectomy is an effective method of polyp removal for small polyps (5 mm to 10 mm). Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) is used for larger polyps (>10 mm). Submucosal injection during EMR or ESD is helpful to prevent complications. However, the effect of submucosal injection in cold snare polypectomy for small polyps is not clear. The aim of this study is to evaluate the risks of bleeding in cold snare polypectomy for small polyps and to investigate the effect of submucosal injection.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
Colonoscopy with polypectomy is frequently performed in pediatric patients based on symptoms, with the majority of polyps identified being benign juvenile pedunculated polyps with a vascular stalk. This is in distinction to adults where polypectomy is often performed as part of a colon cancer screening and prevention strategy and a higher fraction of polyps are sessile and or dysplastic. In adults, polypectomy techniques emphasize a need for deeper resection to ensure complete resection of adenomas or potential carcinoma in situ. Adenomatous polyps can occur in the pediatric age group and may be associated with an underlyi...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Topic of the Month Source Type: research
Colorectal cancer (CRC) typically occurs when precancerous polyps in the colon or in the rectum transform into cancer. Signs of cancer may include rectal bleeding, blood in the stool, or a change in bowel movements. With routine screening, CRC can be prevented or detected early.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research
With more colorectal cancer screening&large polyp removal, delayed post-polypectomy ulcer bleeds (PPUB) are increasing. Risk factors are right colon, sessile configuration, EMR removal, bleeding during polypectomy,&resumption of anti-coagulants&/or dual anti-platelet drugs. Prophylactic clip closure of PPU ’s is reported to be safe but does not reduce delayed PPUB nor is it cost effective. In our studies of patients hospitalized with delayed PPUB, all had ulcers, most with stigmata&arterial blood flow detected by Doppler endoscopic probe (DEP).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcription...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: Also in our experience adenomatous polyps play a crucial role in the development of colorectal cancer. Therefore, it seems quite essential to avert colorectal cancers gradually. Colonoscopy is a non-invasive method of diagnosis and a treatment of colorectal polyps. Proper and careful colonoscopy examination is indispensable in the discovery of colorectal polyps and subsequent follow-up. Timely and routine colonoscopy is considered as an important approach for thwarting the development of malignant neoplasms. KEY WORDS: Adenomatous polyps, Colorectal cancer, Colorectal polyps, Post-polypectomy. PMID: 309...
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Colorectal cancer (CRC) is the fourth leading cause of death worldwide. Yet despite the ability of CRC screening to detect colon cancer early, and to find and remove potentially precancerous growths called polyps, screening rates remain low, below 60%. Experts generally agree that people should be screened for CRC at regular intervals beginning by age 50. Colonoscopy is considered the gold standard for CRC screening. In this procedure, a doctor examines your entire colon through a colonoscope, a flexible tube outfitted with a small video camera and a light. But concern around pre-colonoscopy bowel cleaning, which can be un...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Screening Tests and procedures Source Type: blogs
Case Summary: A 56-year-old man with a history of hypertension and hyperlipidemia was referred by gastroenterology for bleeding per rectum. Because of a family history of colon cancer, he had several prior colonoscopies, most recently 3 years ago, without evidence of pathology. His mother was diagnosed with colon cancer in her mid-40s. His current colonoscopy demonstrated a 2.4 × 1.5 cm cecal adenocarcinoma. Staging workup revealed no evidence of metastatic disease. Because of the patient’s family history, the specimen was further evaluated and found to have high microsatellite instabilit...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Resident’s Corner Source Type: research
Conclusion: The prevalence of polyps and adenomas in this cohort is less than that reported in the Western populations.
Source: The Saudi Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Publication date: December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1864, Issue 12Author(s): Jieun Choo, Gwangbeom Heo, Su Jin Kim, Yunna Lee, Akihito Ishigami, Naoki Maruyama, Hae Young Chung, Eunok ImAbstractSenescence marker protein 30 (SMP30) is a calcium-binding protein whose expression decreases during senescence. SMP30 deficiency increases susceptibility to cytokine-induced apoptosis in the liver and to radiation-induced apoptosis in the small intestine. Furthermore, colonic epithelial cell death is associated with the severity of colitis. Therefore, in the present study, ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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