Peripheral and central nervous system correlates in fibromyalgia

ConclusionsFM patients most commonly showed a mild loss of peripheral nociceptors at the thigh rather than distal small fiber neuropathy. This finding was associated with an altered habituation index and strengthened the hypothesis that central sensitization plays a key role in the pathogenesis of the disease.SignificanceCentral impairment of pain processing likely underlies FM, which in most patients is associated with mild proximal small fiber pathology.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research