Severe polyneuropathy in primary Sj ögren's syndrome : Sjögren's syndrome should be considered in patients with motor neuropathy.
[Severe polyneuropathy in primary Sjögren's syndrome : Sjögren's syndrome should be considered in patients with motor neuropathy]. Z Rheumatol. 2020 May 30;: Authors: Thiele T, Seeliger T, Witte T, Sander B, Skripuletz T, Ernst D Abstract A 64-year-old male patient developed over a period of 20 years a peripheral neuropathy symmetrically affecting the upper and lower limbs. The histological examination of a sural nerve biopsy revealed a severe axonal neuropathy. Despite extensive laboratory investigations including immunological and metabolic tests the origin could not be identified. Finally, a Schirmer test revealed xerophthalmia. A subsequent salivary gland biopsy from the lower lip revealed a grade III lymphocytic inflammation according to Chisholm and Mason and confirmed the diagnosis of Sjögren's syndrome. PMID: 32474638 [PubMed - as supplied by publisher]
This is a review of the evidence from studies of the efficacy and tolerability of topically applied, high-concentration (8%) capsaicin in Chemotherapy-induced peripheral neuropathy (CIPN). Methods: For this review, we searched EMBASE and MEDLINE to 14 April 2020. The terms used in the search included capsaicin patch, chemotherapy-induced peripheral neuropathy, cancer pain or malignant pain. Results: A total of 69 studies were obtained but only 5 were selected for the final analysis. Capsaicin 8% patch provides significant pain relief in CIPN, and may lead to regeneration and restoration of sensory nerve fibers.
We analyzed seven newly homozygous spinocerebellar ataxia type 3 patients from five families and 14 homozygotes reported previously. The AAO was significantly inversely correlated with both the large and small expanded CAG repeats (r = −.7682,p
Condition: Peripheral Neuropathy Due to Chemotherapy Interventions: Other: True acupuncture; Other: Sham acupuncture Sponsor: Instituto Brasileiro de Controle do Cancer Recruiting
Conclusions: Based on the outcomes of the study, it was found that inspiratory muscle training improves inspiratory muscle strength and aerobic capacity without a notable effect on lung functions for diabetic patients suffering from DPN and OSA. PMID: 32626744 [PubMed - in process]
Publication date: September–October 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 14, Issue 5Author(s): Anju M., Saleena Ummer V, Arun G. Maiya, Manjunath Hande, Binu V.S.
Conditions: Diabetic Peripheral Neuropathy; Chinese Medicine; Nerve Conduction Interventions: Drug: LiuWeiLuoBi Decoction; Other: Standard medical treatment Sponsor: China Academy of Chinese Medical Sciences Not yet recruiting
Authors: Wongsaengsak S, Quirch M, Ball S, Sultan A, Jahan N, Elmassry M, Rehman S Abstract Docetaxel is an anti-microtubule agent and a highly effective treatment of locally advanced and metastatic breast cancer. There are several adverse effects associated with docetaxel, such as myelosuppression, peripheral neuropathy, fluid retention, and asthenia. One of the most well-known side-effects of this medication is mild to moderate myalgia. Here, we report a case of a 49-year-old female with stage 3 breast cancers who developed severe acute myositis following docetaxel use. The mechanism of docetaxel-induced myositis...
Authors: Inoue H, Taji H, Yamada K, Iriyama C, Saito T, Kato H, Yanada M, Yamamoto K, Matsukawa N Abstract Dasatinib, a tyrosine kinase inhibitor, is commonly used in the treatment of chronic myelogenous leukemia. A rare side effect is peripheral neuropathy. A 54-year-old woman experienced gradually accelerated dysesthesia and hypoesthesia in her extremities, 2 months following treatment with dasatinib. Nerve conduction studies revealed a prolonged conduction velocity with temporal dispersion, indicating demyelinating peripheral neuropathy. After changing dasatinib to nilotinib, both her clinical symptoms and elect...
We described PK differences related to administration duration and the relation between PK and VCR-induced peripheral neuropathy (VIPN). PK was assessed in 1–5 occasions (1–8 samples in 24 h per occasion). Samples were analyzed using high-performance liquid chromatography/tandem mass spectrometry. Population PK of VCR and its relationship with administration duration was determined using a non-linear mixed effect. We estimated individual post-hoc parameters: area under the concentration time curve (AUC) and maximum concentration (Cmax) in the plasma and peripheral compartment. VIPN was assessed using Co...