Muscle Weakness in Myositis: MicroRNA ‐Mediated Dystrophin Reduction in a Myositis Mouse Model and Human Muscle Biopsies

ConclusionThese data demonstrate that an acquired dystrophin deficiency may occur through NF ‐κB–regulated miRNA s in myositis, thereby suggesting a unifying theme in which muscle injury, inflammation, and weakness are perpetuated both in myositis and in DMD .

Source: Arthritis and Rheumatology - May 30, 2020 Category: Rheumatology Authors: Travis B. Kinder, Christopher R. Heier, Christopher B. Tully, Jack H. Van der Muelen, Eric P. Hoffman, Kanneboyina Nagaraju, Alyson A. Fiorillo Tags: Original Article Source Type: research