The Effect of Patient- and Treatment-Related Factors on Circuit Lifespan During Continuous Renal Replacement Therapy in Critically Ill Children

Objectives:
To examine the effects of patient and treatment variables on circuit lifespan in critically ill children requiring continuous renal replacement therapy.
Design:
Retrospective observational study based on a prospective registry.
Setting:
Tertiary referral 30-bed PICU.
Patients:
One hundred sixty-one critically ill children undergoing continuous renal replacement therapy during an 8-year period (2007–2014) were included in the study.
Interventions:
Continuous renal replacement therapy.
Measurements and Main Results:
During the study period, 161 patients received a total of 22,190 hours of continuous renal replacement therapy, with a median duration of 74.75 hours (interquartile range, 32–169.5) per patient. Of the 572 filter circuits used, 276 (48.3%) were changed due to circuit clotting and 262 (45.8%) were electively changed. Median circuit life was 24.62 hours (interquartile range, 10.6–55.3) for all filters and significantly longer for those electively removed as compared to those prematurely removed because of clotting (35.50 hr [interquartile range, 16.9–67.6] vs 22.00 hr [interquartile range, 13.8–42.5]; p

Source: Pediatric Critical Care Medicine - June 1, 2020 Category: Pediatrics Tags: Renal Critical Care Source Type: research