Don ’t Worry, the Genetics of Obsessive-Compulsive Disorder Is Finally Catching Up

The advent and application of high-throughput sequencing is revolutionizing our understanding of the molecular neurobiology of diverse psychiatric disorders. Whole-genome sequencing, which targets the coding regions of the genome, and whole-exome sequencing are being applied to study multiple psychiatric disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, schizophrenia, and Tourette ’s disorder, among others [(1–3); https://schema.broadinstitute.org]. These studies have demonstrated a role for ultrarare, deleterious, frequently de novo variation in each disorder, and have identified high-confidence genes, including more than 100 high-confidence ASD genes (2).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research