Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro [Research Articles]

In conclusion, our results indicate that ARC39 potently and selectively inhibits ASM in vitro and highlight the need for developing compounds that can reach tissue concentrations sufficient for ASM inhibition in vivo.

Source: The Journal of Lipid Research - May 31, 2020 Category: Lipidology Authors: Naser, E., Kadow, S., Schumacher, F., Mohamed, Z. H., Kappe, C., Hessler, G., Pollmeier, B., Kleuser, B., Arenz, C., Becker, K. A., Gulbins, E., Carpinteiro, A. Tags: Research Articles Source Type: research