Cellular stress orchestrates the localization of hnRNP H to stress granules.

Cellular stress orchestrates the localization of hnRNP H to stress granules.
Exp Cell Res. 2020 May 27;:112111
Authors: Wall ML, Bera A, Wong FK, Lewis SM
Abstract
Heterogeneous nuclear ribonucleoprotein (hnRNP) H is a member of hnRNP H/F protein subfamily of hnRNPs that regulate the maturation and post-transcriptional processing of pre-mRNA. As a component of an mRNA export complex, hnRNP H shuttles mature mRNA from the nucleus to the cytoplasm. Although hnRNP H is primarily a nuclear protein, it can accumulate in the cytoplasm in certain tissues and cell types; however, the physiological relevance of hnRNP H cytoplasmic accumulation is unknown. Here we show that under cellular stress hnRNP H accumulates in the cytoplasm and is required for efficient recovery from cellular stress. Moreover, we find that cytoplasmic hnRNP H localizes to stress granules and that the RRM3 domain of hnRNP H is necessary for this localization. Together, our results demonstrate that hnRNP H accumulates in the cytoplasm under cellular stress and is recruited to stress granules.
PMID: 32473225 [PubMed - as supplied by publisher]

Source: Experimental Cell Research - May 26, 2020 Category: Cytology Authors: Wall ML, Bera A, Wong FK, Lewis SM Tags: Exp Cell Res Source Type: research