Naphthalenones and naphthols isolated from the Saussurea laniceps endophytic fungus Didymella glomerate X223.

Naphthalenones and naphthols isolated from the Saussurea laniceps endophytic fungus Didymella glomerate X223. Chem Biodivers. 2020 May 30;: Authors: Luo G, Chen S, Yu J, Yuan J, Zheng L, Liu L, Chen B, Li J Abstract One new naphthalenone, didymelol A (1), and three new naphthols, didymelol B-D (5-7), together with three known naphthalenones, (3S,4R)-3,4,6,8-tetrahydroxy-3,4-dihydronaphthalen-1(2H)-one (2), (S)-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (3), (S)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (4), were isolated from the Saussurea laniceps endophytic fungus Didymella glomerate X223. The structures of the isolates were elucidated based on extensive spectroscopic data analysis. The absolute configuration of didymelol A (1) was established through single-crystal X-ray diffraction data and didymelols B-D (5-7) were identified through comparisons of experimental and calculated ECD spectra. All compounds were evaluated for cytotoxic activity against human non-small cell lung cancer A549 cells and human breast carcinoma MDA-MB-435 cells. PMID: 32472579 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research