Toolbox for chemically synthesized histone proteins.

Toolbox for chemically synthesized histone proteins.
Curr Opin Chem Biol. 2020 May 27;58:10-19
Authors: Nakatsu K, Hayashi G, Okamoto A
Abstract
Histone post-translational modifications play significant roles in gene regulation processes. Among many approaches, chemical protein synthesis has been a successful and promising method for the preparation of homogeneous products of site-specifically modified histones for elucidation of their biological significance. In this short review, we describe the recent advances in synthetic toolbox for histone proteins such as thioester precursors, chemical ubiquitination, and one-pot peptide ligation.
PMID: 32473259 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - May 26, 2020 Category: Biochemistry Authors: Nakatsu K, Hayashi G, Okamoto A Tags: Curr Opin Chem Biol Source Type: research