What is Dry Needling?
Discussion Myofascial pain is pain from muscle or fascia, and usually associated with myofascial trigger points which are “…a highly localized, hyperirritable spot in a palpable, taut band of skeletal muscle fibers.” Trigger points are common reasons people, especially adults, seek relief in primary care or pain clinic settings. Athletes may also complain of pain caused by them. They are treated in a variety of ways, none of which used as a single method is successful for all individuals. Muscle “…stretching, massage, ischemic compression, laser therapy, transcutaneous electrical nerve stimulation, biofeedback, and pharmacological treatment…” are some options. Learning Point “With dry needling, a solid needle is passed through the skin into muscles, ligaments, tendons, subcutaneous fascia, and scar tissue to relieve or stimulate myofascial trigger points. The practitioner palpates the trigger point, places the need into the position over the target area on the skin, and taps or flicks the top of the needle to penetrate the skin. The needle may be inserted into a muscle to elicit a local twitch response, or into other connective tissue to elicit tissue relaxation. The needle is removed and placed into neighboring areas or allowed to remain in place for two minutes until the trigger-point sensitivity decreases.” It is called “dry” needling as the needles are solid and do not inject any fluid. Dry needling is...
Is erector spinae plane block an effective strategy to improve postsurgical analgesia?BMC Anesthesiology
ConclusionsThe addition of ICT before NCRT seemingly shows no survival benefit on patients with LARC, and might increase the toxicity.
SummaryChemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has demonstrated limited success and is associated with severe side effects. This research aimed to investigate the antitumor efficacy and cytotoxic safety of the conjugate ZHER2:V2-pemetrexed, a novel targeted chemotherapeutic drug. In this context, human epidermal growth factor receptor 2 (HER2) + A549 lung xenografts were treated using ZHER2:V2-pemetrexed, pemetrexed or physiological saline. Therapeutic efficacy was monit...
Conclusion Panitumumab (6 mg/kg iv q 2 weeks) with BKM120 60 mg given 5 out of 7 days per week was declared the RP2D. Toxicities including fatigue, rash and mucositis. There was little evidence of activity in this biomarker unselected cohort.
JULIE COOK: The pain radiating from my abdomen was worse than childbirth. It began on Christmas Eve. I was at home with our children while my husband - a musician - was at work.
DR MARTIN SCURR: Osteoarthritis begins with inflammation, and leads to the gradual loss of cushioning cartilage from the end of the bones that comprise the joint.
Conclusions: SSA could be a valid therapeutic option in patients with MCC with high SR expression. When combined with PD-1/PD-L1 immune-checkpoint inhibition, SSA is likely to enhance antiproliferative activity. Our case report provides the rationale to conduct a prospective trial and translational research to verify the efficacy and safety of combined SSA and checkpoint inhibitors for advanced MCC.
Glioma is the most frequent primary brain tumor that causes high mortality and morbidity with poor prognosis. There are four grades of gliomas, I to IV, among which grade II and III are low-grade glioma (LGG). Although less aggressive, LGG almost universally progresses to high-grade glioma and eventual causes death if lacking of intervention. Current LGG treatment mainly depends on surgical resection followed by radiotherapy and chemotherapy, but the survival rates of LGG patients are low. Therefore, it is necessary to use prognostic biomarkers to classify patients into subgroups with different risks and guide clinical man...
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