Genomic DNA methylation in HLA-Cw*0602 carriers and non-carriers of psoriasis

Psoriasis (Ps) is a chronic immune-mediated skin disorder with a strong and albeit polygenic genetic basis affecting 0.09% –11.4% population worldwide [1], making it a serious global problem. The clinical manifestation, areas of skin lesions and response to the treatment in Ps patients may vary greatly due to the complex interactions between genetics, environmental factors and immune pathways [2]. Increasing evidence have clearly suggested that epigenetic mechanisms, specifically the methylation of cytosine residue at CpG dinucleotides, contributed to the development of Ps [3–5], mainly due to the effect of DNA methylation (DNAm) on the transcriptional regulation and the control of promoter / exon usage and al ternative splicing [6].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research