[Immuno-oncological approaches in the perioperative therapy of muscle invasive bladder cancer].

[Immuno-oncological approaches in the perioperative therapy of muscle invasive bladder cancer].
Urologe A. 2020 May 29;:
Authors: Schmid SC, Koll FJ, Beckert F, Seitz AK
Abstract
Perioperative chemotherapy has become a standard treatment for muscle invasive bladder cancer and is recommended by national and international guidelines. The treatment of metastatic urothelial cancer evolved by the use of immune-modulating therapies like checkpoint inhibitors. Many clinical trials have been initiated which try to evaluate the role of immune checkpoint inhibition in the neoadjuvant and adjuvant setting. These trials focus not only on monotherapy, but also on the combination of checkpoint inhibitors with classical chemotherapy or with local radiation therapy (radioimmunotherapy). In neoadjuvant radioimmunotherapy, the radiation is supposed to act as a sensitizer for the systemic effects of checkpoint inhibition, in addition to the local effects. This review presents and discusses current trials and published results for perioperative immunomodulating treatment-alone or in combination-in muscle invasive bladder cancer.
PMID: 32472221 [PubMed - as supplied by publisher]

Source: Der Urologe. Ausg. A - May 28, 2020 Category: Urology & Nephrology Authors: Schmid SC, Koll FJ, Beckert F, Seitz AK Tags: Urologe A Source Type: research