Early-life factors, in-utero exposures and endometriosis risk: a meta-analysis
Publication date: Available online 14 May 2020Source: Reproductive BioMedicine OnlineAuthor(s): Jessica Ottolina, Matteo Schimberni, Sofia Makieva, Ludovica Bartiromo, Teresa Fazia, Luisa Bernardinelli, Paola Viganò, Massimo Candiani, Davide Gentilini
Conditions: Endometriosis; Cough; Overactive Bladder Intervention: Drug: BAY1817080 Sponsor: Bayer Not yet recruiting
AbstractPurpose of ReviewThe purpose of this review is to summarize the up-to-date pain management options and recommendations for the challenging disease, endometriosis.Recent FindingsThe mainstays of endometriosis advances of both surgical and medical management continue to evolve. Experimental pharmaceuticals include Gestirone, and aromatase inhibitors have shown promise but are still under scrutiny. Surgical techniques include laparoscopic uterosacral nerve ablation/resection and presacral neurectomy.SummaryNo studies have directly compared medical versus surgical management, and as such, no one treatment modality can ...
In conclusion, the relationship between endometriosis and SNP of antioxidant enzymes, GPX4 and TXN2, was confirmed by the present study. According to the result, we suggested that the GPX4 might contribute to the pathogenesis of endometriosis.
Authors: Ashary N, Laheri S, Modi D Abstract The eutherian species evolved an elaborate uterus to allow viviparity. For successful pregnancy, the uterus must not only be differentiated, but must also function optimally and any defects in uterus differentiation and/or function can lead to infertility. The homoebox gene HOXA10 has emerged to be a key player in both uterine development and its optimal functioning in adulthood. Within the Abd-B family, the posterior Hoxa genes play a dominant role in anterio-posterior segmentation of the Müllerian ducts in mammals, with Hoxa10 having a central role in uterine segm...
Researchers found changes to DNA in the uterine cells of women with endometriosis that weren ’t seen in women without the condition.
BLOATING is painful and uncomfortable, and can be caused by a number of things. Does endometriosis cause bloating? Does pelvic inflammatory disease cause it?
The objective of this retros...
Endometriosis is a common gynecologic disorder often associated with severe pelvic pain and infertility with very few known modifiable risk factors. We investigated whether in utero and early life exposures are associated with surgically diagnosed endometriosis among adolescents and young adults.
Abstract Endometriosis is often described as a chronic condition. Surgical or medical treatment approaches do not always cure it, and recurrence of the disease or its symptoms is common. Medical treatment is usually used to achieve symptomatic control whilst surgery aims to eliminate the visible lesions. However, recurrence is frequently seen even after very radical surgery. PMID: 32659035 [PubMed - as supplied by publisher]