Brown tumors of hyperparathyroidism misdiagnosed as multifocal Giant Cell Tumors of bone: A case report

Publication date: September 2020Source: Human Pathology: Case Reports, Volume 21Author(s): Achmad Fauzi Kamal, Putri Amalia Isdianto, Ali Abdullah, Evelina Kodrat
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research

Related Links:

CONCLUSION: There was no difference in hypocalcemia between MWA and TPTX group. Hypocalcemia in the TPTX group might need a longer time to recover. PMID: 32633649 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
AbstractIdentification of variants in the calcium-sensing receptor (CASR) gene is an important means of distinguishing between familial hypocalciuric hypercalcaemia (FHH) and primary hyperparathyroidism. However, identification and bioinformatics analysis of genetic variants alone is now considered insufficient as definitive proof; additional functional assessment is required to diagnose FHH with certainty. We identified two novel variants, D433Y and C739Y, and one previously reported variant G509R in theCASR of four kindreds provisionally diagnosed with FHH and aimed to functionally characterise these variants to confirm ...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Secondary hyperparathyroidism (SHPT) is a common high-risk factor for mortality in end-stage renal disease, and parathyromatosis and supernumerary parathyroid glands are very rare causes of persistent SHPT. Pr...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
Authors: Kaur G, Kulkarni A, Banka S, Gurjar R, Dhaka J, Prajapat R Abstract MEN I inherited as an autosomal dominant disorder leads to hyperplastic/ neoplastic changes in parathyroid, pituitary and endocrine pancreas along with other characteristic tumours. Hyperparathyroidism is the most common manifestation of MEN I. Our case was a female patient aged 42 years who was diagnosed with parathyroid adenoma, coincident with pancreatic neoplasm and adrenal adenoma. Hyperparathyroidism was noted initially and hemiparathyroidectomy was performed. Though adrenal adenoma and pancreatic neoplasm were detected on CECT, pati...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionsDmb treatment not only increased BMD, dependent on bone turnover status, the same as PTX, but also improved LS-TBS. In addition, it did not decrease the level of eGFR, whereas PTX did. These results suggest that Dmb treatment help in the clinical management of osteoporotic patients with PHPT who do not undergo surgery as alternative to PTX.
Source: Endocrine - Category: Endocrinology Source Type: research
ABSTRACT There is no recommendation to investigate celiac disease (CD) in patients with elevated parathyroid hormone (PTH) and normal blood calcium if they are asymptomatic, especially if they do not have hypovitaminosis D. CD was diagnosed in a 30-year-old asymptomatic man without vitamin D deficiency, who had total calcium 9.2 mg/dl, 25-hydroxyvitamin D 36 ng/dl, PTH 112 pg/ml, total IgA 42 mg/dl, anti-tissue transglutaminase (tTG) IgA 22 U/ml. Duodenal biopsy by endoscopy confirmed CD. The patient started a gluten-free diet that was maintained. After six months, the patient had total calcium 9.5 mg/dl, 25-hydroxyvitamin...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
Abstract . PMID: 32598023 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
CONCLUSIONS: In PHPT, correlations between FGF23 and PTH seem rather an epiphenomenon. Therefore, we reckon that FGF23 evaluation and dynamics are not informative regarding PHPT severity. PMID: 32598019 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
ABSTRACTActive vitamin D analogs and calcimimetics are the main therapies used for treating secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD). Peripheral blood mononuclear cells (PBMCs) of 19 pediatric patients with CKD1 ‐5D and 6 healthy donors (HD) were differentiated into mature osteoclasts with RANK‐L and M‐CSF. The effects of single or combined treatment with active vitamin D (1.25‐D) and/or calcimimetic KP2326 were evaluated on osteoclastic differentiation and osteoclastic‐mediated bone resorption. A lthough 1.25‐D inhibited osteoclastic differentiation, a significant resi...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
PMID: 32586826 [PubMed - in process]
Source: The British Journal of General Practice - Category: Primary Care Authors: Tags: Br J Gen Pract Source Type: research
More News: Hyperparathyroidism | Pathology