Ethanol and cannabinoids regulate zebrafish GABAergic neuron development and behavior in a sonic hedgehog and fibroblast growth factor dependent mechanism.

CONCLUSIONS: These studies provide evidence that forebrain GABAergic neuron development, and zebrafish risk-taking behavior, are sensitive to both ethanol and cannabinoid exposure in a Shh- and Fgf-dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of ethanol and cannabinoids in FASD. PMID: 32472575 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research