PErfusioN, OxyGen ConsUmptIon and ENergetics in ADPKD (PENGUIN)

Conditions:   Polycystic Kidney Disease, Adult;   Polycystic Kidney, Autosomal Dominant Interventions:   Drug: Aminohippurate Sodium Inj 20%;   Drug: Iohexol Inj 300 milligrams per milliliter (MG/ML);   Radiation: PET/CT Scan Sponsor:   University of Colorado Denver School of Medicine Barbara Davis Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractGlycocalyx (GCX) is a thin layer of negatively charged glycoproteins that covers the vascular endothelial surface and regulates various biological processes. Because of the delicate and fragile properties of this structure, it is difficult to detect GCX morphologically. We established a simple method for a three-dimensional visualization of endothelial GCX using low-vacuum scanning electron microscopy (LVSEM) on formalin-fixed paraffin-embedded (FFPE) sections. Mouse kidney tissue was fixed with 10% buffered formalin containing 1% Alcian blue (ALB) via perfusion and immersion. FFPE sections were observed by light m...
Source: Medical Molecular Morphology - Category: Molecular Biology Source Type: research
Purpose of review Patients on hemodialysis have significantly higher rates of cardiovascular mortality resulting from a multitude of myocardial dysfunctions. Current imaging modalities allow independent assessment of cardiac morphology, contractile function, coronary arteries and cardiac perfusion. Techniques such as cardiac computed tomography (CT) imaging have been available for some time, but have not yet had widespread adoption because of technical limitations related to cardiac motion, radiation exposure and safety of contrast agents in kidney disease. Recent findings Novel dynamic contrast-enhanced (DCE) CT imag...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: DIAGNOSTICS AND TECHNIQUES: Edited by Maarten W. Taal Source Type: research
CONCLUSIONS AND RELEVANCE: Neuropsychological testing and MRI remain the most widely used diagnostic tests by DLB specialists. Other tests-particularly indicative biomarkers-are used only selectively. Research is needed to validate existing potential DLB biomarkers, develop new biomarkers, and investigate mechanisms to improve DLB diagnosis. PMID: 33009039 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
AbstractPurpose of ReviewEstablishing a diagnosis of ischemic heart disease (IHD) in women, including assessment for coronary microvascular dysfunction (CMD) when indicated, can be challenging. Access to performance of invasive testing when appropriate may be limited, and noninvasive imaging assessments have evolved. This review will summarize the various noninvasive imaging modalities available for the diagnosis of IHD and CMD in women, outlining indications, performance modalities, advantages, and limitations.Recent FindingsWhile stress echocardiography and single photon emission computed tomography (SPECT) myocardial pe...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
CONCLUSION: Precise assessment of oxidation via 11 C-acetate PET requires prior information about blood volume which can be obtained by DCE-MRI or 68 Ga-DOTA PET. Since perfusion can change rapidly, simultaneous PET-MRI would be preferred. PMID: 33010059 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Magn Reson Med Source Type: research
Conclusions: No significant differences were found in peripapillary and macular microcirculation detected by OCTA between AD and ED glaucomatous eyes. Peripapillary and macular microcirculation were significantly correlated with disease severity in AD and ED glaucomatous eyes.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
CONCLUSION: The current PFOB-FTAC micro-droplet sonosensitizers provided a large and sustained enhancement of the HIFU thermal deposition at the focal area, suggesting solutions for less technological constraints, lower risk for the near-/far- field heating. We also report a suitable experimental model for other MRgHIFU studies. PMID: 32990101 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Semin Musculoskelet Radiol 2020; 24: 337-354 DOI: 10.1055/s-0040-1708823Radiologic imaging is crucial for diagnosing and monitoring rheumatic inflammatory diseases. Particularly the emerging approach of precision medicine has increased the interest in quantitative imaging. Extensive research has shown that ultrasound allows a quantification of direct signs such as bone erosions and synovial thickness. Dual-energy X-ray absorptiometry and high-resolution peripheral quantitative computed tomography (CT) contribute to the quantitative assessment of secondary signs such as osteoporosis or lean mass loss. Magnetic resonance ima...
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
Condition:   Glioblastoma Interventions:   Other: FDG PET;   Other: CT scan;   Other: Magnetic resonance imaging (MRI) Sponsor:   Centre Hospitalier Universitaire de Nīmes Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: While none of described methods enables the simultaneous measurement of all microcirculatory parameters, certain techniques are widely used in arterial hypertension research, while others gain popularity in screening. PMID: 32969283 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
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