GSE140955 RNAseq of 2'3' cGAMP injected Drosophila melanogaster

Contributors : Hua Cai ; Andreas Holleufer ; Bine Simonsen ; Juliette Schneider ; Aur élie Lemoine ; Hans-Henrik Gad ; Jingxian Huang ; Hieqing Huang ; Di Chen ; Tao Peng ; João T Marques ; Rune Hartmann ; Nelson Martins ; Jean-Luc ImlerSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterWe recently reported that an orthologue of STING regulates infection by picorna-like viruses in drosophila. Here, we show that injection of flies with 2 ’3’-cGAMP can induce expression of dSTING-regulated genes. Analysis of the transcriptome of 2’3’-cGAMP injected flies reveals a complex pattern of response, with early and late induced genes. Our results reveal that dSTING regulates an NF-κB -dependent antiviral program, which predates the emergence of Interferon Regulatory Factors and interferons in vertebrates.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research