Bevacizumab (Avastin ®) in cancer treatment: A review of 15 years of clinical experience and future outlook

Cancer cells differ fundamentally from normal cells, as a result of having acquired hallmark capabilities that enable tumor growth and progression [1]. Due to their high metabolic demands, growing solid tumors depend on vascularization for provision of nutrients and oxygen and disposal of metabolic waste products. Vascularization can be promoted by angiogenesis, i.e. the generation of new blood vessels by sprouting from existing blood vessels. In normal physiology, angiogenesis plays a vital role in the generation of new vasculature during embryogenesis, but it is mostly quiescent in the adult body, with transient activation during wound healing and the female reproductive cycle.

Source: Cancer Treatment Reviews - March 25, 2020 Category: Cancer & Oncology Authors: Josep Garcia, Herbert I. Hurwitz, Alan B. Sandler, David Miles, Robert L Coleman, Regula Deurloo, Olivier L Chinot Tags: Anti-tumour Treatment Source Type: research