Alpinetin Protects Chondrocytes and Exhibits Anti-Inflammatory Effects via the NF- κB/ERK Pathway for Alleviating Osteoarthritis

In conclusion, APT appears to favorably modulate anti-inflammatory effects in chondrocytes making it a promising compound for OA treatment.Graphical AbstractInhibitory effects of Alpinetin on TNF- α-induced NF-κB activation resulted in destruction of cartilage in rat OA chondrocytesin vitro. The TNF- α receptor were stimulated by TNF-α, activating the cytoplasmic IκBα kinases(IKKS), then IKKs will be phosphorylated, and subsequently degraded by the ubiquitin-proteasome system. NF-κB transfer to the nucleus and bind various NF-κB regulates the NF-κB recognition site in the promoter region. Which triggers the gene expression of pro-inflammatory and pro-apoptotic. However, Alpinetin could inhibits the NF-κB signaling pathway in different ways: APT inhibits IκBα phosphorylation, preventing phosphorylated ubiquitination of IκBα further. Moreover, APT blocks translocation of the act ivated NF-κB to the nucleus, to protect the cartilage tissue from damage.
Source: Inflammation - Category: Allergy & Immunology Source Type: research