Contribution of selected vasoactive systems to blood pressure regulation in two models of chronic kidney disease.

Contribution of selected vasoactive systems to blood pressure regulation in two models of chronic kidney disease. Physiol Res. 2020 May 29; Authors: Drábková N, Hojná S, Zicha J, Vaněčková I Abstract It is generally accepted that angiotensin II plays an important role in high blood pressure (BP) development in both 2-kidney-1-clip (2K1C) Goldblatt hypertension and partial nephrectomy (NX) model of chronic kidney disease (CKD). The contribution of sympathetic nervous system and nitric oxide to BP control in these models is less clear. Partial nephrectomy or stenosis of the renal artery was performed in adult (10-week-old) male hypertensive heterozygous Ren-2 transgenic rats (TGR) and normotensive control Hannover Sprague Dawley (HanSD) rats and in Wistar rats. One and four weeks after the surgery, basal blood pressure (BP) and acute BP responses to the consecutive blockade of renin-angiotensin (RAS), sympathetic nervous (SNS), and nitric oxide (NO) systems were determined in conscious rats. Both surgical procedures increased plasma urea, a marker of renal damage; the effect being more pronounced following partial nephrectomy in hypertensive TGR than in normotensive HanSD rats with a substantially smaller effect in Wistar rats after renal artery stenosis. We demonstrated that the renin-angiotensin system does not play so significant role in blood pressure maintenance during hypertension development in either CKD model. By contras...
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research