Perfluoroalkyl substances cause Leydig cell dysfunction as endocrine disruptors.

Perfluoroalkyl substances cause Leydig cell dysfunction as endocrine disruptors.
Chemosphere. 2020 Aug;253:126764
Authors: Zhu Q, Li H, Wen Z, Wang Y, Li X, Huang T, Mo J, Wu Y, Zhong Y, Ge RS
Abstract
Perfluoroalkyl substances (PFASs) are a group of man-made organic substances. Some of PFASs have been classified as persistent organic pollutants and endocrine disruptors. They might interfere with the male sex endocrine system, causing the abnormal development of the male reproductive tract and failure of pubertal onset and infertility. The present review discusses the development and function of two generations of Leydig cells in rodents and the effects of PFASs on Leydig cell development after their exposure in gestational and postnatal periods. We also discuss human epidemiological data for the effects of PFASs on male sex hormone levels. The structure-activity relationship of PFASs on Leydig cell steroidogenesis and enzyme activities are also discussed.
PMID: 32464778 [PubMed - in process]

Source: Chemosphere - May 30, 2020 Category: Chemistry Authors: Zhu Q, Li H, Wen Z, Wang Y, Li X, Huang T, Mo J, Wu Y, Zhong Y, Ge RS Tags: Chemosphere Source Type: research